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Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant org...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200844/ https://www.ncbi.nlm.nih.gov/pubmed/25238416 http://dx.doi.org/10.3390/ijms150916522 |
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author | Arlia-Ciommo, Anthony Piano, Amanda Svistkova, Veronika Mohtashami, Sadaf Titorenko, Vladimir I. |
author_facet | Arlia-Ciommo, Anthony Piano, Amanda Svistkova, Veronika Mohtashami, Sadaf Titorenko, Vladimir I. |
author_sort | Arlia-Ciommo, Anthony |
collection | PubMed |
description | Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. |
format | Online Article Text |
id | pubmed-4200844 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-42008442014-10-17 Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid Arlia-Ciommo, Anthony Piano, Amanda Svistkova, Veronika Mohtashami, Sadaf Titorenko, Vladimir I. Int J Mol Sci Review Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. MDPI 2014-09-18 /pmc/articles/PMC4200844/ /pubmed/25238416 http://dx.doi.org/10.3390/ijms150916522 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
spellingShingle | Review Arlia-Ciommo, Anthony Piano, Amanda Svistkova, Veronika Mohtashami, Sadaf Titorenko, Vladimir I. Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title | Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title_full | Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title_fullStr | Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title_full_unstemmed | Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title_short | Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid |
title_sort | mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200844/ https://www.ncbi.nlm.nih.gov/pubmed/25238416 http://dx.doi.org/10.3390/ijms150916522 |
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