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Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid

Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant org...

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Autores principales: Arlia-Ciommo, Anthony, Piano, Amanda, Svistkova, Veronika, Mohtashami, Sadaf, Titorenko, Vladimir I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200844/
https://www.ncbi.nlm.nih.gov/pubmed/25238416
http://dx.doi.org/10.3390/ijms150916522
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author Arlia-Ciommo, Anthony
Piano, Amanda
Svistkova, Veronika
Mohtashami, Sadaf
Titorenko, Vladimir I.
author_facet Arlia-Ciommo, Anthony
Piano, Amanda
Svistkova, Veronika
Mohtashami, Sadaf
Titorenko, Vladimir I.
author_sort Arlia-Ciommo, Anthony
collection PubMed
description Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research.
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spelling pubmed-42008442014-10-17 Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid Arlia-Ciommo, Anthony Piano, Amanda Svistkova, Veronika Mohtashami, Sadaf Titorenko, Vladimir I. Int J Mol Sci Review Bile acids are cholesterol-derived bioactive lipids that play essential roles in the maintenance of a heathy lifespan. These amphipathic molecules with detergent-like properties display numerous beneficial effects on various longevity- and healthspan-promoting processes in evolutionarily distant organisms. Recent studies revealed that lithocholic bile acid not only causes a considerable lifespan extension in yeast, but also exhibits a substantial cytotoxic effect in cultured cancer cells derived from different tissues and organisms. The molecular and cellular mechanisms underlying the robust anti-aging and anti-tumor effects of lithocholic acid have emerged. This review summarizes the current knowledge of these mechanisms, outlines the most important unanswered questions and suggests directions for future research. MDPI 2014-09-18 /pmc/articles/PMC4200844/ /pubmed/25238416 http://dx.doi.org/10.3390/ijms150916522 Text en © 2014 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
spellingShingle Review
Arlia-Ciommo, Anthony
Piano, Amanda
Svistkova, Veronika
Mohtashami, Sadaf
Titorenko, Vladimir I.
Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title_full Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title_fullStr Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title_full_unstemmed Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title_short Mechanisms Underlying the Anti-Aging and Anti-Tumor Effects of Lithocholic Bile Acid
title_sort mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4200844/
https://www.ncbi.nlm.nih.gov/pubmed/25238416
http://dx.doi.org/10.3390/ijms150916522
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