Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples c...

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Detalles Bibliográficos
Autores principales: de Camargo, Priscila Cilene León Bueno, Afonso, José Eduardo, Samano, Marcos Naoyuki, Acencio, Milena Marques Pagliarelli, Antonangelo, Leila, Teixeira, Ricardo Henrique de Oliveira Braga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201174/
https://www.ncbi.nlm.nih.gov/pubmed/25210966
http://dx.doi.org/10.1590/S1806-37132014000400011
Descripción
Sumario:Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.

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