Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation

Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples c...

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Autores principales: de Camargo, Priscila Cilene León Bueno, Afonso, José Eduardo, Samano, Marcos Naoyuki, Acencio, Milena Marques Pagliarelli, Antonangelo, Leila, Teixeira, Ricardo Henrique de Oliveira Braga
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Sociedade Brasileira de Pneumologia e Tisiologia 2014
Materias:
Brief Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201174/
https://www.ncbi.nlm.nih.gov/pubmed/25210966
http://dx.doi.org/10.1590/S1806-37132014000400011
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author de Camargo, Priscila Cilene León Bueno
Afonso, José Eduardo
Samano, Marcos Naoyuki
Acencio, Milena Marques Pagliarelli
Antonangelo, Leila
Teixeira, Ricardo Henrique de Oliveira Braga
author_facet de Camargo, Priscila Cilene León Bueno
Afonso, José Eduardo
Samano, Marcos Naoyuki
Acencio, Milena Marques Pagliarelli
Antonangelo, Leila
Teixeira, Ricardo Henrique de Oliveira Braga
author_sort de Camargo, Priscila Cilene León Bueno
collection PubMed
description Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients.
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spelling pubmed-42011742014-10-21 Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation de Camargo, Priscila Cilene León Bueno Afonso, José Eduardo Samano, Marcos Naoyuki Acencio, Milena Marques Pagliarelli Antonangelo, Leila Teixeira, Ricardo Henrique de Oliveira Braga J Bras Pneumol Brief Communication Our objective was to determine the levels of lactate dehydrogenase, IL-6, IL-8, and VEGF, as well as the total and differential cell counts, in the pleural fluid of lung transplant recipients, correlating those levels with the occurrence and severity of rejection. We analyzed pleural fluid samples collected from 18 patients at various time points (up to postoperative day 4). The levels of IL-6, IL-8, and VEGF tended to elevate in parallel with increases in the severity of rejection. Our results suggest that these levels are markers of acute graft rejection in lung transplant recipients. Sociedade Brasileira de Pneumologia e Tisiologia 2014 /pmc/articles/PMC4201174/ /pubmed/25210966 http://dx.doi.org/10.1590/S1806-37132014000400011 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communication
de Camargo, Priscila Cilene León Bueno
Afonso, José Eduardo
Samano, Marcos Naoyuki
Acencio, Milena Marques Pagliarelli
Antonangelo, Leila
Teixeira, Ricardo Henrique de Oliveira Braga
Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title_full Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title_fullStr Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title_full_unstemmed Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title_short Cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
title_sort cytokine levels in pleural fluid as markers of acute rejection after lung transplantation
topic Brief Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201174/
https://www.ncbi.nlm.nih.gov/pubmed/25210966
http://dx.doi.org/10.1590/S1806-37132014000400011
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