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Human high-altitude adaptation: forward genetics meets the HIF pathway

Humans have adapted to the chronic hypoxia of high altitude in several locations, and recent genome-wide studies have indicated a genetic basis. In some populations, genetic signatures have been identified in the hypoxia-inducible factor (HIF) pathway, which orchestrates the transcriptional response...

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Detalles Bibliográficos
Autores principales:	Bigham, Abigail W., Lee, Frank S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Cold Spring Harbor Laboratory Press 2014
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201282/ https://www.ncbi.nlm.nih.gov/pubmed/25319824 http://dx.doi.org/10.1101/gad.250167.114

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