Crystal structure of a Fanconi anemia-associated nuclease homolog bound to 5′ flap DNA: basis of interstrand cross-link repair by FAN1

Fanconi anemia (FA) is an autosomal recessive genetic disorder caused by defects in any of 15 FA genes responsible for processing DNA interstrand cross-links (ICLs). The ultimate outcome of the FA pathway is resolution of cross-links, which requires structure-selective nucleases. FA-associated nucle...

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Detalles Bibliográficos
Autores principales: Gwon, Gwang Hyeon, Kim, Youngran, Liu, Yaqi, Watson, Adam T., Jo, Aera, Etheridge, Thomas J., Yuan, Fenghua, Zhang, Yanbin, Kim, YoungChang, Carr, Anthony M., Cho, Yunje
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201288/
https://www.ncbi.nlm.nih.gov/pubmed/25319828
http://dx.doi.org/10.1101/gad.248492.114

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