Structural and mechanistic insights into Mcm2–7 double-hexamer assembly and function

Eukaryotic cells license each DNA replication origin during G1 phase by assembling a prereplication complex that contains a Mcm2–7 (minichromosome maintenance proteins 2–7) double hexamer. During S phase, each Mcm2–7 hexamer forms the core of a replicative DNA helicase. However, the mechanisms of or...

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Detalles Bibliográficos
Autores principales: Sun, Jingchuan, Fernandez-Cid, Alejandra, Riera, Alberto, Tognetti, Silvia, Yuan, Zuanning, Stillman, Bruce, Speck, Christian, Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201289/
https://www.ncbi.nlm.nih.gov/pubmed/25319829
http://dx.doi.org/10.1101/gad.242313.114

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