Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling

[Image: see text] Advances in hydroarylation have been achieved by the development of a one-pot regioselective allene hydrosilylation/Pd(0)-catalyzed cross-coupling protocol. The regioselectivity is primarily governed by N-heterocyclic carbene (NHC) ligand identity in the hydrosilylation step and is...

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Autores principales: Miller, Zachary D., Montgomery, John
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201326/
https://www.ncbi.nlm.nih.gov/pubmed/25275880
http://dx.doi.org/10.1021/ol502766q
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author Miller, Zachary D.
Montgomery, John
author_facet Miller, Zachary D.
Montgomery, John
author_sort Miller, Zachary D.
collection PubMed
description [Image: see text] Advances in hydroarylation have been achieved by the development of a one-pot regioselective allene hydrosilylation/Pd(0)-catalyzed cross-coupling protocol. The regioselectivity is primarily governed by N-heterocyclic carbene (NHC) ligand identity in the hydrosilylation step and is preserved in the subsequent cross-coupling reaction. This methodology affords streamlined access to functionalized 1,1-disubstituted alkenes with excellent regiocontrol.
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spelling pubmed-42013262015-10-02 Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling Miller, Zachary D. Montgomery, John Org Lett [Image: see text] Advances in hydroarylation have been achieved by the development of a one-pot regioselective allene hydrosilylation/Pd(0)-catalyzed cross-coupling protocol. The regioselectivity is primarily governed by N-heterocyclic carbene (NHC) ligand identity in the hydrosilylation step and is preserved in the subsequent cross-coupling reaction. This methodology affords streamlined access to functionalized 1,1-disubstituted alkenes with excellent regiocontrol. American Chemical Society 2014-10-02 2014-10-17 /pmc/articles/PMC4201326/ /pubmed/25275880 http://dx.doi.org/10.1021/ol502766q Text en Copyright © 2014 American Chemical Society Terms of Use (http://pubs.acs.org/page/policy/authorchoice_termsofuse.html)
spellingShingle Miller, Zachary D.
Montgomery, John
Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title_full Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title_fullStr Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title_full_unstemmed Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title_short Regioselective Allene Hydroarylation via One-Pot Allene Hydrosilylation/Pd-Catalyzed Cross-Coupling
title_sort regioselective allene hydroarylation via one-pot allene hydrosilylation/pd-catalyzed cross-coupling
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201326/
https://www.ncbi.nlm.nih.gov/pubmed/25275880
http://dx.doi.org/10.1021/ol502766q
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