Bioinformatic and Biochemical Characterizations of C–S Bond Formation and Cleavage Enzymes in the Fungus Neurospora crassa Ergothioneine Biosynthetic Pathway

[Image: see text] Ergothioneine is a histidine thiol derivative. Its mycobacterial biosynthetic pathway has five steps (EgtA-E catalysis) with two novel reactions: a mononuclear nonheme iron enzyme (EgtB) catalyzed oxidative C–S bond formation and a PLP-mediated C–S lyase (EgtE) reaction. Our bioinf...

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Detalles Bibliográficos
Autores principales: Hu, Wen, Song, Heng, Sae Her, Ampon, Bak, Daniel W., Naowarojna, Nathchar, Elliott, Sean J., Qin, Li, Chen, Xiaoping, Liu, Pinghua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201327/
https://www.ncbi.nlm.nih.gov/pubmed/25275953
http://dx.doi.org/10.1021/ol502596z

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