Structure-Guided Functional Characterization of Enediyne Self-Sacrifice Resistance Proteins, CalU16 and CalU19

[Image: see text] Calicheamicin γ(1)(I) (1) is an enediyne antitumor compound produced by Micromonospora echinospora spp. calichensis, and its biosynthetic gene cluster has been previously reported. Despite extensive analysis and biochemical study, several genes in the biosynthetic gene cluster of 1...

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Detalles Bibliográficos
Autores principales: Elshahawi, Sherif I., Ramelot, Theresa A., Seetharaman, Jayaraman, Chen, Jing, Singh, Shanteri, Yang, Yunhuang, Pederson, Kari, Kharel, Madan K., Xiao, Rong, Lew, Scott, Yennamalli, Ragothaman M., Miller, Mitchell D., Wang, Fengbin, Tong, Liang, Montelione, Gaetano T., Kennedy, Michael A., Bingman, Craig A., Zhu, Haining, Phillips, George N., Thorson, Jon S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2014
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201346/
https://www.ncbi.nlm.nih.gov/pubmed/25079510
http://dx.doi.org/10.1021/cb500327m

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