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Transition-State Analysis of 2-O-Acetyl-ADP-Ribose Hydrolysis by Human Macrodomain 1

[Image: see text] Macrodomains, including the human macrodomain 1 (MacroD1), are erasers of the post-translational modification of monoadenosinediphospho-ribosylation and hydrolytically deacetylate the sirtuin product O-acetyl-ADP-ribose (OAADPr). OAADPr has been reported to play a role in cell sign...

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Detalles Bibliográficos
Autores principales:	Hirsch, Brett M., Burgos, Emmanuel S., Schramm, Vern L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201351/ https://www.ncbi.nlm.nih.gov/pubmed/25051211 http://dx.doi.org/10.1021/cb500485w

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