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Computational Insights into the Inhibitory Mechanism of Human AKT1 by an Orally Active Inhibitor, MK-2206

The AKT signaling pathway has been identified as an important target for cancer therapy. Among small-molecule inhibitors of AKT that have shown tremendous potential in inhibiting cancer, MK-2206 is a highly potent, selective and orally active allosteric inhibitor. Promising preclinical anticancer re...

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Detalles Bibliográficos
Autores principales:	Rehan, Mohd, Beg, Mohd A., Parveen, Shadma, Damanhouri, Ghazi A., Zaher, Galila F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201482/ https://www.ncbi.nlm.nih.gov/pubmed/25329478 http://dx.doi.org/10.1371/journal.pone.0109705

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