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PLK1 and β-TrCP-Dependent Ubiquitination and Degradation of Rap1GAP Controls Cell Proliferation

Rap1GAP is a GTPase-activating protein (GAP) that specifically stimulates the GTP hydrolysis of Rap1 GTPase. Although Rap1GAP is recognized as a tumor suppressor gene and downregulated in various cancers, little is known regarding the regulation of Rap1GAP ubiquitination and degradation under physio...

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Detalles Bibliográficos
Autores principales:	Wang, Dejie, Zhang, Pingzhao, Gao, Kun, Tang, Yan, Jin, Xiaofeng, Zhang, Yuanyuan, Yi, Qing, Wang, Chenji, Yu, Long
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201484/ https://www.ncbi.nlm.nih.gov/pubmed/25329897 http://dx.doi.org/10.1371/journal.pone.0110296

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