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A Roadmap for Natural Product Discovery Based on Large-Scale Genomics and Metabolomics
Actinobacteria encode a wealth of natural product biosynthetic gene clusters (NPGCs), whose systematic study is complicated by numerous repetitive motifs. By combining several metrics we developed a method for global classification of these gene clusters into families (GCFs) and analyzed the biosynt...
Autores principales: | Doroghazi, James R., Albright, Jessica C., Goering, Anthony W., Ju, Kou-San, Haines, Robert R., Tchalukov, Konstantin A., Labeda, David P., Kelleher, Neil L., Metcalf, William W. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201863/ https://www.ncbi.nlm.nih.gov/pubmed/25262415 http://dx.doi.org/10.1038/nchembio.1659 |
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