Unraveling the mechanism of cell death induced by chemical fibrils

We previously discovered a small-molecule inducer of cell death, named 1541, that non-covalently self-assembles into chemical fibrils (“chemi-fibrils”) and activates procaspase-3 in vitro. We report here that 1541-induced cell death is caused by the fibrillar, rather than the soluble form of the dru...

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Detalles Bibliográficos
Autores principales: Julien, Olivier, Kampmann, Martin, Bassik, Michael C., Zorn, Julie A., Venditto, Vincent J., Shimbo, Kazutaka, Agard, Nicholas J., Shimada, Kenichi, Rheingold, Arnold L., Stockwell, Brent R., Weissman, Jonathan S., Wells, James A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201873/
https://www.ncbi.nlm.nih.gov/pubmed/25262416
http://dx.doi.org/10.1038/nchembio.1639

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201873/
https://www.ncbi.nlm.nih.gov/pubmed/25262416
http://dx.doi.org/10.1038/nchembio.1639

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