Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis

The tumor suppressor protein Par-4, which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds to vimentin, displaces...

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Autores principales: Burikhanov, Ravshan, Sviripa, Vitaliy M., Hebbar, Nikhil, Zhang, Wen, Layton, W. John, Hamza, Adel, Zhan, Chang-Guo, Watt, David S., Liu, Chunming, Rangnekar, Vivek M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2014
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201913/
https://www.ncbi.nlm.nih.gov/pubmed/25218743
http://dx.doi.org/10.1038/nchembio.1631
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author Burikhanov, Ravshan
Sviripa, Vitaliy M.
Hebbar, Nikhil
Zhang, Wen
Layton, W. John
Hamza, Adel
Zhan, Chang-Guo
Watt, David S.
Liu, Chunming
Rangnekar, Vivek M.
author_facet Burikhanov, Ravshan
Sviripa, Vitaliy M.
Hebbar, Nikhil
Zhang, Wen
Layton, W. John
Hamza, Adel
Zhan, Chang-Guo
Watt, David S.
Liu, Chunming
Rangnekar, Vivek M.
author_sort Burikhanov, Ravshan
collection PubMed
description The tumor suppressor protein Par-4, which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds to vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells.
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spelling pubmed-42019132015-05-01 Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis Burikhanov, Ravshan Sviripa, Vitaliy M. Hebbar, Nikhil Zhang, Wen Layton, W. John Hamza, Adel Zhan, Chang-Guo Watt, David S. Liu, Chunming Rangnekar, Vivek M. Nat Chem Biol Article The tumor suppressor protein Par-4, which is secreted by normal cells, selectively induces apoptosis in cancer cells. We identified a 3-arylquinoline derivative, designated Arylquin 1, as a potent Par-4 secretagogue in cell cultures and mice. Mechanistically, Arylquin 1 binds to vimentin, displaces Par-4 from vimentin for secretion and triggers the efficient paracrine apoptosis of diverse cancer cells. Thus, targeting vimentin with Par-4 secretagogues efficiently induces paracrine apoptosis of tumor cells. 2014-09-14 2014-11 /pmc/articles/PMC4201913/ /pubmed/25218743 http://dx.doi.org/10.1038/nchembio.1631 Text en http://www.nature.com/authors/editorial_policies/license.html#terms Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use:http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Burikhanov, Ravshan
Sviripa, Vitaliy M.
Hebbar, Nikhil
Zhang, Wen
Layton, W. John
Hamza, Adel
Zhan, Chang-Guo
Watt, David S.
Liu, Chunming
Rangnekar, Vivek M.
Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title_full Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title_fullStr Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title_full_unstemmed Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title_short Arylquins Target Vimentin to Trigger Par-4 Secretion for Tumor Cell Apoptosis
title_sort arylquins target vimentin to trigger par-4 secretion for tumor cell apoptosis
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4201913/
https://www.ncbi.nlm.nih.gov/pubmed/25218743
http://dx.doi.org/10.1038/nchembio.1631
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