Cargando…

Overcoming EMT-associated resistance to anti-cancer drugs via Src/FAK pathway inhibition

Epithelial to mesenchymal transition (EMT) is a key process in embryonic development and has been associated with cancer metastasis and drug resistance. For example, in EGFR mutated non-small cell lung cancers (NSCLC), EMT has been associated with acquired resistance to the EGFR inhibitor erlotinib....

Descripción completa

Detalles Bibliográficos
Autores principales:	Wilson, Catherine, Nicholes, Katrina, Bustos, Daisy, Lin, Eva, Song, Qinghua, Stephan, Jean-Philippe, Kirkpatrick, Donald S., Settleman, Jeff
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Priority Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202126/ https://www.ncbi.nlm.nih.gov/pubmed/25193862

Ejemplares similares

MUC1-C confers EMT and KRAS independence in mutant KRAS lung cancer cells
por: Kharbanda, Akriti, et al.
Publicado: (2014)

A new class of small molecule estrogen receptor-alpha antagonists that overcome anti-estrogen resistance
por: Ma, Yongxian, et al.
Publicado: (2015)

Macrophage depletion through colony stimulating factor 1 receptor pathway blockade overcomes adaptive resistance to anti-VEGF therapy
por: Lyons, Yasmin A., et al.
Publicado: (2017)

SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer
por: Gururajan, Murali, et al.
Publicado: (2015)

Comparison of SARS-CoV-2 RT-PCR on a high-throughput molecular diagnostic platform and the cobas SARS-CoV-2 test for the diagnostic of COVID-19 on various clinical samples
por: Opota, Onya, et al.
Publicado: (2020)

LINC00520 is induced by Src, STAT3, and PI3K and plays a functional role in breast cancer
por: Henry, Whitney S., et al.
Publicado: (2016)

Homeobox B7 accelerates the cancer progression of gastric carcinoma cells by promoting epithelial–mesenchymal transition (EMT) and activating Src–FAK pathway
por: Wu, Jianghong, et al.
Publicado: (2019)

Tetraspanin 7 promotes osteosarcoma cell invasion and metastasis by inducing EMT and activating the FAK-Src-Ras-ERK1/2 signaling pathway
por: Shao, Shijie, et al.
Publicado: (2022)

Regulation of E-cadherin localization by microtubule targeting agents: rapid promotion of cortical E-cadherin through p130Cas/Src inhibition by eribulin
por: Dybdal-Hargreaves, Nicholas F., et al.
Publicado: (2017)

Simultaneous deactivation of FAK and Src improves the pathology of hypertrophic scar
por: Su, Linlin, et al.
Publicado: (2016)

Leptin Promotes Expression of EMT-Related Transcription Factors and Invasion in a Src and FAK-Dependent Pathway in MCF10A Mammary Epithelial Cells
por: Olea-Flores, Monserrat, et al.
Publicado: (2019)

Combined BRAF(V600E)- and SRC-inhibition induces apoptosis, evokes an immune response and reduces tumor growth in an immunocompetent orthotopic mouse model of anaplastic thyroid cancer
por: Borre, Pierre Vanden, et al.
Publicado: (2014)

Concurrent inhibition of FAK/SRC and MEK overcomes MEK inhibitor resistance in Neurofibromatosis Type I related malignant peripheral nerve sheath tumors
por: Gu, Yihui, et al.
Publicado: (2022)

FAK competes for Src to promote migration against invasion in melanoma cells
por: Kolli-Bouhafs, K, et al.
Publicado: (2014)

Inhibition of epithelial cell migration and Src/FAK signaling by SIRT3
por: Lee, Jaewon J., et al.
Publicado: (2018)

MMP-11 promoted the oral cancer migration and FAK/Src activation
por: Hsin, Chung-Han, et al.
Publicado: (2017)

Conjugation to the sigma-2 ligand SV119 overcomes uptake blockade and converts dm-Erastin into a potent pancreatic cancer therapeutic
por: Ohman, Kerri A., et al.
Publicado: (2016)

Therapeutic inhibition of USP7-PTEN network in chronic lymphocytic leukemia: a strategy to overcome TP53 mutated/deleted clones
por: Carrà, Giovanna, et al.
Publicado: (2017)

TRP channels and temperature in airway disease—clinical significance
por: Millqvist, Eva
Publicado: (2015)

AKT inhibition overcomes rapamycin resistance by enhancing the repressive function of PRAS40 on mTORC1/4E-BP1 axis
por: Mi, Wenting, et al.
Publicado: (2015)

Correlation between FAK and EGF-Induced EMT in Colorectal Cancer Cells
por: Huang, Kun, et al.
Publicado: (2020)

Dissociation of FAK/p130(CAS)/c-Src Complex during Mitosis: Role of Mitosis-specific Serine Phosphorylation of FAK
por: Yamakita, Yoshihiko, et al.
Publicado: (1999)

Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks
por: Schoenherr, Christina, et al.
Publicado: (2017)

Molecular properties of CD133+ glioblastoma stem cells derived from treatment-refractory recurrent brain tumors
por: Liu, Qinghai, et al.
Publicado: (2009)

Overcoming resistance to single-agent therapy for oncogenic BRAF gene fusions via combinatorial targeting of MAPK and PI3K/mTOR signaling pathways
por: Jain, Payal, et al.
Publicado: (2017)

Visualization of Src and FAK Activity during the Differentiation Process from HMSCs to Osteoblasts
por: Liao, Xiaoling, et al.
Publicado: (2012)

The dual kinase complex FAK-Src as a promising therapeutic target in cancer
por: Bolós, Victoria, et al.
Publicado: (2010)

The Effect of Differentiation Induction on FAK and Src Activity in Live HMSCs Visualized by FRET
por: Liao, Xiaoling, et al.
Publicado: (2013)

Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition
por: Horton, Edward R., et al.
Publicado: (2016)

Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells
por: Schoenherr, Christina, et al.
Publicado: (2014)

Vemurafenib-resistance via de novo RBM genes mutations and chromosome 5 aberrations is overcome by combined therapy with palbociclib in thyroid carcinoma with BRAF(V600E)
por: Antonello, Zeus A., et al.
Publicado: (2017)

Characterization of Leukemic Resistance to CD19-Targeted CAR T-cell Therapy through Deep Genomic Sequencing
por: Chen, Gregory M., et al.
Publicado: (2023)

Anti-GPR56 monoclonal antibody potentiates GPR56-mediated Src-Fak signaling to modulate cell adhesion
por: Chatterjee, Treena, et al.
Publicado: (2021)

Tyrosine phosphorylation of cortactin by the FAK-Src complex at focal adhesions regulates cell motility
por: Wang, Wenqi, et al.
Publicado: (2011)

MICA Expression Is Regulated by Cell Adhesion and Contact in a FAK/Src-Dependent Manner
por: Moncayo, Gerald, et al.
Publicado: (2017)

Src SUMOylation Inhibits Tumor Growth Via Decreasing FAK Y925 Phosphorylation
por: Wang, Jing, et al.
Publicado: (2017)

COVID-19 and thermoregulation-related problems: Practical recommendations
por: Daanen, Hein, et al.
Publicado: (2020)

Targeting MAPK/NF-κB Pathways in Anti-Inflammatory Potential of Rutaecarpine: Impact on Src/FAK-Mediated Macrophage Migration
por: Jayakumar, Thanasekaran, et al.
Publicado: (2021)

The BRD4–NUT Fusion Alone Drives Malignant Transformation of NUT Carcinoma
por: Durall, R. Taylor, et al.
Publicado: (2023)

Enhanced antitumor effects by combining an IL-12/anti-DNA fusion protein with avelumab, an anti-PD-L1 antibody
por: Fallon, Jonathan K., et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_raoafjcvt18q6s6vr02ob220d6