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(18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation
The aim of this study was to investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT). All patients h...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202130/ https://www.ncbi.nlm.nih.gov/pubmed/25277179 |
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author | Lapa, Constantin Lückerath, Katharina Malzahn, Uwe Samnick, Samuel Einsele, Herrmann Buck, Andreas K. Herrmann, Ken Knop, Stefan |
author_facet | Lapa, Constantin Lückerath, Katharina Malzahn, Uwe Samnick, Samuel Einsele, Herrmann Buck, Andreas K. Herrmann, Ken Knop, Stefan |
author_sort | Lapa, Constantin |
collection | PubMed |
description | The aim of this study was to investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT). All patients had been heavily pretreated. Time to progression (TTP) and overall survival (OS) were correlated to a number of different PET-derived as well as clinical parameters. Impact on patient management was assessed. Absence of FDG-avid MM foci was a positive prognostic factor for both TTP and OS (p<0.01). Presence of >10 focal lesions correlated with both TTP (p<0.01) and OS (p<0.05). Interestingly, presence of >10 lesions in the appendicular skeleton proved to have the strongest association with disease progression. Intensity of glucose uptake and presence of extramedullary disease were associated with shorter TTP (p=0.037 and p=0.049, respectively). Manifestations in soft tissue structures turned out to be a strong negative predictor for both, TTP and OS (p<0.01, respectively). PET resulted in a change of management in 30% of patients. Our data underline the prognostic value of 18F-FDG-PET/CT in MM patients also in the setting of post-SCT relapse. PET/CT has a significant impact on patient management. |
format | Online Article Text |
id | pubmed-4202130 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-42021302014-10-21 (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation Lapa, Constantin Lückerath, Katharina Malzahn, Uwe Samnick, Samuel Einsele, Herrmann Buck, Andreas K. Herrmann, Ken Knop, Stefan Oncotarget Clinical Research Paper The aim of this study was to investigate the prognostic value of 18F-fluorodeoxyglucose positron emission tomography–computed tomography (18F-FDG-PET/CT) in 37 patients with a history of multiple myeloma (MM) and suspected or confirmed recurrence after stem cell transplantation (SCT). All patients had been heavily pretreated. Time to progression (TTP) and overall survival (OS) were correlated to a number of different PET-derived as well as clinical parameters. Impact on patient management was assessed. Absence of FDG-avid MM foci was a positive prognostic factor for both TTP and OS (p<0.01). Presence of >10 focal lesions correlated with both TTP (p<0.01) and OS (p<0.05). Interestingly, presence of >10 lesions in the appendicular skeleton proved to have the strongest association with disease progression. Intensity of glucose uptake and presence of extramedullary disease were associated with shorter TTP (p=0.037 and p=0.049, respectively). Manifestations in soft tissue structures turned out to be a strong negative predictor for both, TTP and OS (p<0.01, respectively). PET resulted in a change of management in 30% of patients. Our data underline the prognostic value of 18F-FDG-PET/CT in MM patients also in the setting of post-SCT relapse. PET/CT has a significant impact on patient management. Impact Journals LLC 2014-07-31 /pmc/articles/PMC4202130/ /pubmed/25277179 Text en Copyright: © 2014 Lapa et al. http://creativecommons.org/licenses/by/2.5/ This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Clinical Research Paper Lapa, Constantin Lückerath, Katharina Malzahn, Uwe Samnick, Samuel Einsele, Herrmann Buck, Andreas K. Herrmann, Ken Knop, Stefan (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title | (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title_full | (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title_fullStr | (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title_full_unstemmed | (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title_short | (18)FDG-PET/CT for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
title_sort | (18)fdg-pet/ct for prognostic stratification of patients with multiple myeloma relapse after stem cell transplantation |
topic | Clinical Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202130/ https://www.ncbi.nlm.nih.gov/pubmed/25277179 |
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