Inhibition of protein phosphatase 2A with a small molecule LB100 radiosensitizes nasopharyngeal carcinoma xenografts by inducing mitotic catastrophe and blocking DNA damage repair

Nasopharyngeal carcinoma (NPC), while uncommon worldwide, is a major health problem in China. Although local radiation and surgery provide good control of NPC, better treatments that permit reductions in radiation dosing are needed. Inhibition of protein phosphatase 2A (PP2A), a ubiquitous multifunc...

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Detalles Bibliográficos
Autores principales: Lv, Peng, Wang, Yue, Ma, Jie, Wang, Zheng, Li, Jing-Li, Hong, Christopher S., Zhuang, Zhengping, Zeng, Yi-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202140/
https://www.ncbi.nlm.nih.gov/pubmed/25245035

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