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Osteoblast-derived WISP-1 increases VCAM-1 expression and enhances prostate cancer metastasis by down-regulating miR-126

Bone metastases of prostate cancer (PCa) may cause intractable pain. Wnt-induced secreted protein-1 (WISP-1) belongs to the CCN family (CTGF/CYR61/NOV) that plays a key role in bone formation. We found that osteoblast-conditioned medium (OBCM) stimulates migration and vascular cell adhesion molecule...

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Detalles Bibliográficos
Autores principales:	Tai, Huai-Ching, Chang, An-Chen, Yu, Hong-Jeng, Huang, Chao-Yuan, Tsai, Yu-Chieh, Lai, Yu-Wei, Sun, Hui-Lung, Tang, Chih-Hsin, Wang, Shih-Wei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2014
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202146/ https://www.ncbi.nlm.nih.gov/pubmed/25277191

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