A highly efficient tumor-infiltrating MDSC differentiation system for discovery of anti-neoplastic targets, which circumvents the need for tumor establishment in mice

Myeloid-derived suppressor cells (MDSCs) exhibit potent immunosuppressive activities in cancer. MDSCs infiltrate tumors and strongly inhibit cancer-specific cytotoxic T cells. Their mechanism of differentiation and identification of MDSC-specific therapeutic targets are major areas of interest. We h...

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Detalles Bibliográficos
Autores principales: Liechtenstein, Therese, Perez-Janices, Noemi, Gato, Maria, Caliendo, Fabio, Kochan, Grazyna, Blanco-Luquin, Idoia, Van der Jeught, Kevin, Arce, Frederick, Guerrero-Setas, David, Fernandez-Irigoyen, Joaquin, Santamaria, Enrique, Breckpot, Karine, Escors, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2014
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202165/
https://www.ncbi.nlm.nih.gov/pubmed/25151659

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