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Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection

Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection...

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Autores principales: Michitaka, Kojiro, Hiraoka, Atsushi, Tokumoto, Yoshio, Ninomiya, Keiko, Ninomiya, Tomoyuki, Horiike, Norio, Abe, Masanori, Hiasa, Yoichi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi Publishing Corporation 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202240/
https://www.ncbi.nlm.nih.gov/pubmed/25349743
http://dx.doi.org/10.1155/2014/358206
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author Michitaka, Kojiro
Hiraoka, Atsushi
Tokumoto, Yoshio
Ninomiya, Keiko
Ninomiya, Tomoyuki
Horiike, Norio
Abe, Masanori
Hiasa, Yoichi
author_facet Michitaka, Kojiro
Hiraoka, Atsushi
Tokumoto, Yoshio
Ninomiya, Keiko
Ninomiya, Tomoyuki
Horiike, Norio
Abe, Masanori
Hiasa, Yoichi
author_sort Michitaka, Kojiro
collection PubMed
description Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection.
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spelling pubmed-42022402014-10-27 Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection Michitaka, Kojiro Hiraoka, Atsushi Tokumoto, Yoshio Ninomiya, Keiko Ninomiya, Tomoyuki Horiike, Norio Abe, Masanori Hiasa, Yoichi Int J Hepatol Research Article Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection. Hindawi Publishing Corporation 2014 2014-10-02 /pmc/articles/PMC4202240/ /pubmed/25349743 http://dx.doi.org/10.1155/2014/358206 Text en Copyright © 2014 Kojiro Michitaka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Michitaka, Kojiro
Hiraoka, Atsushi
Tokumoto, Yoshio
Ninomiya, Keiko
Ninomiya, Tomoyuki
Horiike, Norio
Abe, Masanori
Hiasa, Yoichi
Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title_full Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title_fullStr Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title_full_unstemmed Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title_short Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
title_sort clinical features of adult patients with acute hepatitis b virus infection progressing to chronic infection
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202240/
https://www.ncbi.nlm.nih.gov/pubmed/25349743
http://dx.doi.org/10.1155/2014/358206
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