Cargando…
Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection
Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection...
Autores principales: | , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202240/ https://www.ncbi.nlm.nih.gov/pubmed/25349743 http://dx.doi.org/10.1155/2014/358206 |
_version_ | 1782340280723177472 |
---|---|
author | Michitaka, Kojiro Hiraoka, Atsushi Tokumoto, Yoshio Ninomiya, Keiko Ninomiya, Tomoyuki Horiike, Norio Abe, Masanori Hiasa, Yoichi |
author_facet | Michitaka, Kojiro Hiraoka, Atsushi Tokumoto, Yoshio Ninomiya, Keiko Ninomiya, Tomoyuki Horiike, Norio Abe, Masanori Hiasa, Yoichi |
author_sort | Michitaka, Kojiro |
collection | PubMed |
description | Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection. |
format | Online Article Text |
id | pubmed-4202240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-42022402014-10-27 Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection Michitaka, Kojiro Hiraoka, Atsushi Tokumoto, Yoshio Ninomiya, Keiko Ninomiya, Tomoyuki Horiike, Norio Abe, Masanori Hiasa, Yoichi Int J Hepatol Research Article Background. Information regarding the progression of acute hepatitis B virus (HBV) infection to chronic infection in adults is scarce. Methods. Twenty-five adult patients with acute HBV infection (14 men and 11 women, 18–84 years old), whose clinical features progressed to those of chronic infection (group A) or did not (group B), were studied retrospectively. Results. There were 3 and 22 patients in groups A and B, respectively. Two of the 3 patients of group A lacked the typical symptoms of acute hepatitis. No differences were found between groups with respect to age, sex, or HBV genotypes. However, total bilirubin and alanine aminotransaminase levels were significantly lower in group A. Conclusions. Three of the 25 adult patients with acute HBV infection progressed to chronic infection. Hepatitis was mild in these patients. Patients with mild acute hepatitis B or unapparent HBV infection may have a higher risk of progressing to chronic infection. Hindawi Publishing Corporation 2014 2014-10-02 /pmc/articles/PMC4202240/ /pubmed/25349743 http://dx.doi.org/10.1155/2014/358206 Text en Copyright © 2014 Kojiro Michitaka et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Michitaka, Kojiro Hiraoka, Atsushi Tokumoto, Yoshio Ninomiya, Keiko Ninomiya, Tomoyuki Horiike, Norio Abe, Masanori Hiasa, Yoichi Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title_full | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title_fullStr | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title_full_unstemmed | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title_short | Clinical Features of Adult Patients with Acute Hepatitis B Virus Infection Progressing to Chronic Infection |
title_sort | clinical features of adult patients with acute hepatitis b virus infection progressing to chronic infection |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202240/ https://www.ncbi.nlm.nih.gov/pubmed/25349743 http://dx.doi.org/10.1155/2014/358206 |
work_keys_str_mv | AT michitakakojiro clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT hiraokaatsushi clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT tokumotoyoshio clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT ninomiyakeiko clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT ninomiyatomoyuki clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT horiikenorio clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT abemasanori clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection AT hiasayoichi clinicalfeaturesofadultpatientswithacutehepatitisbvirusinfectionprogressingtochronicinfection |