Cargando…

Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats

BACKGROUND: Several studies have been shown that antidepressant drugs have contradictory effects on cognitive processes. Therefore, the aim of this study was to investigate the effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus (DG) of the hippocampal formation in ra...

Descripción completa

Detalles Bibliográficos
Autores principales: Zarei, Ghasem, Reisi, Parham, Alaei, Hojjatallah, Javanmard, Shaghayegh Haghjooye
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medknow Publications & Media Pvt Ltd 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202498/
https://www.ncbi.nlm.nih.gov/pubmed/25337529
http://dx.doi.org/10.4103/2277-9175.142044
_version_ 1782340301486030848
author Zarei, Ghasem
Reisi, Parham
Alaei, Hojjatallah
Javanmard, Shaghayegh Haghjooye
author_facet Zarei, Ghasem
Reisi, Parham
Alaei, Hojjatallah
Javanmard, Shaghayegh Haghjooye
author_sort Zarei, Ghasem
collection PubMed
description BACKGROUND: Several studies have been shown that antidepressant drugs have contradictory effects on cognitive processes. Therefore, the aim of this study was to investigate the effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus (DG) of the hippocampal formation in rat. MATERIALS AND METHODS: Experimental groups were the control, the fluoxetine, and amitriptyline. The rats were treated for 21 days and then, paired pulse facilitation/inhibition (PPF/I) and long-term potentiation (LTP) in perforant path-DG synapses were assessed (by 400 Hz tetanization). Field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude were measured. RESULTS: The results of PPF/I showed that PS amplitude ratios were increased in 10-70 ms inter-stimulus intervals in the amitriptyline group compared to the control group. In the fluoxetine group, EPSP slope ratios were decreased in intervals 30, 40, and 50 ms inter-stimulus intervals compared to the control group. The PS-LTP was significantly lower in the fluoxetine and the amitriptyline groups with respect to the control group. CONCLUSION: The results showed that fluoxetine and amitriptyline affect synaptic plasticity in the hippocampus and these effects is probably due to the impact on the number of active neurons.
format Online
Article
Text
id pubmed-4202498
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Medknow Publications & Media Pvt Ltd
record_format MEDLINE/PubMed
spelling pubmed-42024982014-10-21 Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats Zarei, Ghasem Reisi, Parham Alaei, Hojjatallah Javanmard, Shaghayegh Haghjooye Adv Biomed Res Original Article BACKGROUND: Several studies have been shown that antidepressant drugs have contradictory effects on cognitive processes. Therefore, the aim of this study was to investigate the effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus (DG) of the hippocampal formation in rat. MATERIALS AND METHODS: Experimental groups were the control, the fluoxetine, and amitriptyline. The rats were treated for 21 days and then, paired pulse facilitation/inhibition (PPF/I) and long-term potentiation (LTP) in perforant path-DG synapses were assessed (by 400 Hz tetanization). Field excitatory post-synaptic potential (fEPSP) slope and population spike (PS) amplitude were measured. RESULTS: The results of PPF/I showed that PS amplitude ratios were increased in 10-70 ms inter-stimulus intervals in the amitriptyline group compared to the control group. In the fluoxetine group, EPSP slope ratios were decreased in intervals 30, 40, and 50 ms inter-stimulus intervals compared to the control group. The PS-LTP was significantly lower in the fluoxetine and the amitriptyline groups with respect to the control group. CONCLUSION: The results showed that fluoxetine and amitriptyline affect synaptic plasticity in the hippocampus and these effects is probably due to the impact on the number of active neurons. Medknow Publications & Media Pvt Ltd 2014-09-30 /pmc/articles/PMC4202498/ /pubmed/25337529 http://dx.doi.org/10.4103/2277-9175.142044 Text en Copyright: © 2014 Zarei. http://creativecommons.org/licenses/by-nc-sa/3.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Original Article
Zarei, Ghasem
Reisi, Parham
Alaei, Hojjatallah
Javanmard, Shaghayegh Haghjooye
Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title_full Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title_fullStr Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title_full_unstemmed Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title_short Effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
title_sort effects of amitriptyline and fluoxetine on synaptic plasticity in the dentate gyrus of hippocampal formation in rats
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202498/
https://www.ncbi.nlm.nih.gov/pubmed/25337529
http://dx.doi.org/10.4103/2277-9175.142044
work_keys_str_mv AT zareighasem effectsofamitriptylineandfluoxetineonsynapticplasticityinthedentategyrusofhippocampalformationinrats
AT reisiparham effectsofamitriptylineandfluoxetineonsynapticplasticityinthedentategyrusofhippocampalformationinrats
AT alaeihojjatallah effectsofamitriptylineandfluoxetineonsynapticplasticityinthedentategyrusofhippocampalformationinrats
AT javanmardshaghayeghhaghjooye effectsofamitriptylineandfluoxetineonsynapticplasticityinthedentategyrusofhippocampalformationinrats