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Cell Therapy in Spinal Cord Injury: a Mini- Reivew
Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202537/ https://www.ncbi.nlm.nih.gov/pubmed/25337345 |
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author | Mehrabi, Soraya Eftekhari, Sanaz Moradi, Fateme Delaviz, Hamdollah Pourheidar, Bagher Azizi, Monir Zendehdel, Adib Shahbazi, Ali Joghataei, Mohammad Taghi |
author_facet | Mehrabi, Soraya Eftekhari, Sanaz Moradi, Fateme Delaviz, Hamdollah Pourheidar, Bagher Azizi, Monir Zendehdel, Adib Shahbazi, Ali Joghataei, Mohammad Taghi |
author_sort | Mehrabi, Soraya |
collection | PubMed |
description | Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, our more recent strategy was application of cytokines. We observed a significant improvement in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI. |
format | Online Article Text |
id | pubmed-4202537 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42025372014-10-21 Cell Therapy in Spinal Cord Injury: a Mini- Reivew Mehrabi, Soraya Eftekhari, Sanaz Moradi, Fateme Delaviz, Hamdollah Pourheidar, Bagher Azizi, Monir Zendehdel, Adib Shahbazi, Ali Joghataei, Mohammad Taghi Basic Clin Neurosci Commentary Spinal cord injury (SCI) is a debilitating disease which leads to progressive functional damages. Because of limited axonal regeneration in the central nervous system, there is no or little recovery expected in the patients. Different cellular and molecular approaches were investigated in SCI animal models. Cellular transplantation of stem cells can potentially replace damaged tissue and provide a suitable microenvironment for axons to regenerate. Here, we reviewed the last approaches applied by our colleagues and others in order to improve axonal regeneration following SCI. We used different types of stem cells via different methods. First, fetal olfactory mucosa, schwann, and bone marrow stromal cells were transplanted into the injury sites in SCI models. In later studies, was applied simultaneous transplantation of stem cells with chondroitinase ABC in SCI models with the aid of nanoparticles. Using these approaches, considerable functional recovery was observed. However, considering some challenges in stem cell therapy such as rejection, infection, and development of a new cancer, our more recent strategy was application of cytokines. We observed a significant improvement in motor function of rats when stromal derived factor-1 was used to attract innate stem cells to the injury site. In conclusion, it seems that co-transplantation of different cells accompanies with other factors like enzymes and growth factors via new delivery systems may yield better results in SCI. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202537/ /pubmed/25337345 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Commentary Mehrabi, Soraya Eftekhari, Sanaz Moradi, Fateme Delaviz, Hamdollah Pourheidar, Bagher Azizi, Monir Zendehdel, Adib Shahbazi, Ali Joghataei, Mohammad Taghi Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title | Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title_full | Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title_fullStr | Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title_full_unstemmed | Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title_short | Cell Therapy in Spinal Cord Injury: a Mini- Reivew |
title_sort | cell therapy in spinal cord injury: a mini- reivew |
topic | Commentary |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202537/ https://www.ncbi.nlm.nih.gov/pubmed/25337345 |
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