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The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics

INTRODUCTION: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects....

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Autores principales: Moghimi, Ali, Mollazadeh, Samaneh, Rassouli, Fatemeh Behnam, Shiee, Reza, Khalilzade, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202555/
https://www.ncbi.nlm.nih.gov/pubmed/25337325
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author Moghimi, Ali
Mollazadeh, Samaneh
Rassouli, Fatemeh Behnam
Shiee, Reza
Khalilzade, Mohammad Ali
author_facet Moghimi, Ali
Mollazadeh, Samaneh
Rassouli, Fatemeh Behnam
Shiee, Reza
Khalilzade, Mohammad Ali
author_sort Moghimi, Ali
collection PubMed
description INTRODUCTION: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. METHODS: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. RESULTS: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. DISCUSSION: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy.
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spelling pubmed-42025552014-10-21 The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics Moghimi, Ali Mollazadeh, Samaneh Rassouli, Fatemeh Behnam Shiee, Reza Khalilzade, Mohammad Ali Basic Clin Neurosci Research Papers INTRODUCTION: Ciprofloxacin which was used in this study is a Fluoroquinolone (FQ). This kind of drug may cause epileptic seizures probably because of the inhibition of GABA binding to its receptors. Wag/Rij rats (an animal model for generalized absence epilepsy), were used as experimental subjects. METHODS: For EEG study, electrodes were inserted into the cortex of animals according to paxinos coordinates. After and before ciprofloxacin injection, EEG was recorded and their SWDs were compared with each others. RESULTS: Findings showed a significant increase in the mean number of seizures during recording period. But the mean number of SWDs during seizures did not show any significant differences between groups. DISCUSSION: These results may be due to involvement of GABA antagonistic effects of FQs and/or Mg2+ linked blockade of NMDA receptors. More researches are going to determine physiopathology of SWDs and find new effective substance against this kind of epilepsy. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202555/ /pubmed/25337325 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Research Papers
Moghimi, Ali
Mollazadeh, Samaneh
Rassouli, Fatemeh Behnam
Shiee, Reza
Khalilzade, Mohammad Ali
The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title_full The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title_fullStr The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title_full_unstemmed The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title_short The Effect of Ciprofloxacin Injection on Genetically Absence Prone (Wag/Rij) Rat's Electroencephalogram Characteristics
title_sort effect of ciprofloxacin injection on genetically absence prone (wag/rij) rat's electroencephalogram characteristics
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202555/
https://www.ncbi.nlm.nih.gov/pubmed/25337325
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