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Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus

INTRODUCTION: MDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) admini...

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Autores principales: Jahanshahi, Mehrdad, Haidari, Kamran, Mahaki-Zadeh, Simin, Nikmahzar, EmseGol, Babakordi, Fatemeh
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202557/
https://www.ncbi.nlm.nih.gov/pubmed/25337329
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author Jahanshahi, Mehrdad
Haidari, Kamran
Mahaki-Zadeh, Simin
Nikmahzar, EmseGol
Babakordi, Fatemeh
author_facet Jahanshahi, Mehrdad
Haidari, Kamran
Mahaki-Zadeh, Simin
Nikmahzar, EmseGol
Babakordi, Fatemeh
author_sort Jahanshahi, Mehrdad
collection PubMed
description INTRODUCTION: MDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) administration of MDMA on rats’ memory and their hippocampal cell density. METHOD: Young adult male Wistar rats 200 ± 20 g served as subjects. The rats were randomly distributed into three MDMA treated groups (3×2.5 mg/kg, 3×5 mg/kg, 3×10 mg/kg) and one control-saline group. All animals received MDMA intraperitoneally (3h apart; a challenge) 7th day of every week for consecutive 4 weeks. Animals were trained before and were tested after injections for their memory status using the standards passive avoidance method. Finally, 24hr after the memory test, rats were sacrificed and after tissue operations, the hippocampal astrocytes and neurons were counted. RESULTS: Results showed that the number of neurons in all experimental groups was lower than the control-saline group. The most decreased number of neurons was shown in 5 mg/kg MDMA group compared to control-saline in all the regions of hippocampus. Also we found that repeated administration of MDMA reduced the number of hippocampal astrocytes. DISCUSSION: It is concluded that repeated administration of MDMA can reduce density of neurons and astrocytes and this decrease is not dose dependence.
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spelling pubmed-42025572014-10-21 Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus Jahanshahi, Mehrdad Haidari, Kamran Mahaki-Zadeh, Simin Nikmahzar, EmseGol Babakordi, Fatemeh Basic Clin Neurosci Research Papers INTRODUCTION: MDMA or ecstasy is a derivative of amphetamines used mostly by young people worldwide. Although the acute effects of this drug are known, the effect of chronic administration is not well studied. Therefor the aim of this study was to determine the effects of repeated (long term) administration of MDMA on rats’ memory and their hippocampal cell density. METHOD: Young adult male Wistar rats 200 ± 20 g served as subjects. The rats were randomly distributed into three MDMA treated groups (3×2.5 mg/kg, 3×5 mg/kg, 3×10 mg/kg) and one control-saline group. All animals received MDMA intraperitoneally (3h apart; a challenge) 7th day of every week for consecutive 4 weeks. Animals were trained before and were tested after injections for their memory status using the standards passive avoidance method. Finally, 24hr after the memory test, rats were sacrificed and after tissue operations, the hippocampal astrocytes and neurons were counted. RESULTS: Results showed that the number of neurons in all experimental groups was lower than the control-saline group. The most decreased number of neurons was shown in 5 mg/kg MDMA group compared to control-saline in all the regions of hippocampus. Also we found that repeated administration of MDMA reduced the number of hippocampal astrocytes. DISCUSSION: It is concluded that repeated administration of MDMA can reduce density of neurons and astrocytes and this decrease is not dose dependence. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202557/ /pubmed/25337329 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Research Papers
Jahanshahi, Mehrdad
Haidari, Kamran
Mahaki-Zadeh, Simin
Nikmahzar, EmseGol
Babakordi, Fatemeh
Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title_full Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title_fullStr Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title_full_unstemmed Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title_short Effects of Repeated Administration of 3,4-methylenedioxymethamphetamine (MDMA) on Avoidance Memory and Cell Density in Rats’ Hippocampus
title_sort effects of repeated administration of 3,4-methylenedioxymethamphetamine (mdma) on avoidance memory and cell density in rats’ hippocampus
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202557/
https://www.ncbi.nlm.nih.gov/pubmed/25337329
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