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Septo-Hippocampo-Septal Loop and Memory Formation
The Cholinergic and GABAergic fibers of the medial septal/diagonal band of Broca (MS/ DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the sep...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202558/ https://www.ncbi.nlm.nih.gov/pubmed/25337323 |
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author | Khakpai, Fatemeh Nasehi, Mohammad Haeri-Rohani, Ali Eidi, Akram Zarrindast, Mohammad Reza |
author_facet | Khakpai, Fatemeh Nasehi, Mohammad Haeri-Rohani, Ali Eidi, Akram Zarrindast, Mohammad Reza |
author_sort | Khakpai, Fatemeh |
collection | PubMed |
description | The Cholinergic and GABAergic fibers of the medial septal/diagonal band of Broca (MS/ DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitter systems including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and other systems-mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus. |
format | Online Article Text |
id | pubmed-4202558 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42025582014-10-21 Septo-Hippocampo-Septal Loop and Memory Formation Khakpai, Fatemeh Nasehi, Mohammad Haeri-Rohani, Ali Eidi, Akram Zarrindast, Mohammad Reza Basic Clin Neurosci Review Papers The Cholinergic and GABAergic fibers of the medial septal/diagonal band of Broca (MS/ DB) area project to the hippocampus and constitute the septo-hippocampal pathway, which has been proven to play a role in learning and memory. In addition, the hippocampus has bidirectional connections with the septum so that to self-regulate of cholinergic input. The activity of septal and hippocampal neurons is modulated by several neurotransmitter systems including glutamatergic neurons from the entorhinal cortex, serotonergic fibers from the raphe nucleus, dopaminergic neurons from the ventral tegmental area (VTA), histaminergic cells from the tuberomammillary nucleus and adrenergic fibers from the locus coeruleus (LC). Thus, changes in the glutamatergic, serotonergic and other systems-mediated transmission in the MS/DB may influence cholinergic or GABAergic transmission in the hippocampus. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202558/ /pubmed/25337323 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Review Papers Khakpai, Fatemeh Nasehi, Mohammad Haeri-Rohani, Ali Eidi, Akram Zarrindast, Mohammad Reza Septo-Hippocampo-Septal Loop and Memory Formation |
title | Septo-Hippocampo-Septal Loop and Memory Formation |
title_full | Septo-Hippocampo-Septal Loop and Memory Formation |
title_fullStr | Septo-Hippocampo-Septal Loop and Memory Formation |
title_full_unstemmed | Septo-Hippocampo-Septal Loop and Memory Formation |
title_short | Septo-Hippocampo-Septal Loop and Memory Formation |
title_sort | septo-hippocampo-septal loop and memory formation |
topic | Review Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202558/ https://www.ncbi.nlm.nih.gov/pubmed/25337323 |
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