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The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whethe...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2013
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202567/ https://www.ncbi.nlm.nih.gov/pubmed/25337351 |
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author | Keshvari, Fatemeh Pouretemad, Hamid-Reza Ekhtiari, Hamed |
author_facet | Keshvari, Fatemeh Pouretemad, Hamid-Reza Ekhtiari, Hamed |
author_sort | Keshvari, Fatemeh |
collection | PubMed |
description | INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies the working memory function in healthy adults. METHODS: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded. RESULTS: A repeated measures, mixed design ANOVA indicated a significant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically significant changes in speed of working memory [F(1,55)= 0.458,P=0.502] related to type or order of stimulation. DISCUSSION: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory. |
format | Online Article Text |
id | pubmed-4202567 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2013 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42025672014-10-21 The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory Keshvari, Fatemeh Pouretemad, Hamid-Reza Ekhtiari, Hamed Basic Clin Neurosci Research Papers INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies the working memory function in healthy adults. METHODS: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded. RESULTS: A repeated measures, mixed design ANOVA indicated a significant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically significant changes in speed of working memory [F(1,55)= 0.458,P=0.502] related to type or order of stimulation. DISCUSSION: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202567/ /pubmed/25337351 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Research Papers Keshvari, Fatemeh Pouretemad, Hamid-Reza Ekhtiari, Hamed The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title_full | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title_fullStr | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title_full_unstemmed | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title_short | The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory |
title_sort | polarity-dependent effects of the bilateral brain stimulation on working memory |
topic | Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202567/ https://www.ncbi.nlm.nih.gov/pubmed/25337351 |
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