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The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory

INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whethe...

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Autores principales: Keshvari, Fatemeh, Pouretemad, Hamid-Reza, Ekhtiari, Hamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2013
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202567/
https://www.ncbi.nlm.nih.gov/pubmed/25337351
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author Keshvari, Fatemeh
Pouretemad, Hamid-Reza
Ekhtiari, Hamed
author_facet Keshvari, Fatemeh
Pouretemad, Hamid-Reza
Ekhtiari, Hamed
author_sort Keshvari, Fatemeh
collection PubMed
description INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies the working memory function in healthy adults. METHODS: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded. RESULTS: A repeated measures, mixed design ANOVA indicated a significant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically significant changes in speed of working memory [F(1,55)= 0.458,P=0.502] related to type or order of stimulation. DISCUSSION: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory.
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spelling pubmed-42025672014-10-21 The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory Keshvari, Fatemeh Pouretemad, Hamid-Reza Ekhtiari, Hamed Basic Clin Neurosci Research Papers INTRODUCTION: Working memory plays a critical role in cognitive processes which are central to our daily life. Neuroimaging studies have shown that one of the most important areas corresponding to the working memory is the dorsolateral prefrontal cortex (DLFPC). This study was aimed to assess whether bilateral modulation of the DLPFC using a noninvasive brain stimulation, namely transcranial direct current stimulation (tDCS), modifies the working memory function in healthy adults. METHODS: In a randomized sham-controlled cross-over study, 60 subjects (30 Males) received sham and active tDCS in two subgroups (anode left/cathode right and anode right/cathode left) of the DLPFC. Subjects were presented working memory n-back task while the reaction time and accuracy were recorded. RESULTS: A repeated measures, mixed design ANOVA indicated a significant difference between the type of stimulation (sham vs. active) in anodal stimulation of the left DLPFC with cathodal stimulation of the right DLPFC [F(1,55)= 5.29, P=0.019], but not the inverse polarity worsened accuracy in the 2-back working memory task. There were also no statistically significant changes in speed of working memory [F(1,55)= 0.458,P=0.502] related to type or order of stimulation. DISCUSSION: The results would imply to a polarity dependence of bilateral tDCS of working memory. Left anodal/ right cathodal stimulation of DLPFC could impair working memory, while the reverser stimulation had no effect. Meaning that bilateral stimulation of DLFC would not be a useful procedure to improve working memory. Further studies are required to understand subtle effects of different tDCS stimulation/inhibition electrode positioning on the working memory. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202567/ /pubmed/25337351 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Research Papers
Keshvari, Fatemeh
Pouretemad, Hamid-Reza
Ekhtiari, Hamed
The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title_full The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title_fullStr The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title_full_unstemmed The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title_short The Polarity-Dependent Effects of the Bilateral Brain Stimulation on Working Memory
title_sort polarity-dependent effects of the bilateral brain stimulation on working memory
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202567/
https://www.ncbi.nlm.nih.gov/pubmed/25337351
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