Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment

INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. B...

Descripción completa

Detalles Bibliográficos
Autores principales: Asl, Sara Soleimani, Pourheydar, Bagher, Dabaghian, Fataneh, Nezhadi, Akram, Roointan, Amir, Mehdizadeh, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202580/
https://www.ncbi.nlm.nih.gov/pubmed/25337365
Descripción
Sumario:INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. RESULTS: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p < 0.001). Ginger administration however, appeared to significantly decrease the same (p < 0.001). DISCUSSION: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.

Ejemplares similares