Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment

INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. B...

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Autores principales: Asl, Sara Soleimani, Pourheydar, Bagher, Dabaghian, Fataneh, Nezhadi, Akram, Roointan, Amir, Mehdizadeh, Mehdi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Iranian Neuroscience Society 2013
Materias:
Research Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202580/
https://www.ncbi.nlm.nih.gov/pubmed/25337365
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author Asl, Sara Soleimani
Pourheydar, Bagher
Dabaghian, Fataneh
Nezhadi, Akram
Roointan, Amir
Mehdizadeh, Mehdi
author_facet Asl, Sara Soleimani
Pourheydar, Bagher
Dabaghian, Fataneh
Nezhadi, Akram
Roointan, Amir
Mehdizadeh, Mehdi
author_sort Asl, Sara Soleimani
collection PubMed
description INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. RESULTS: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p < 0.001). Ginger administration however, appeared to significantly decrease the same (p < 0.001). DISCUSSION: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity.
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spelling pubmed-42025802014-10-21 Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment Asl, Sara Soleimani Pourheydar, Bagher Dabaghian, Fataneh Nezhadi, Akram Roointan, Amir Mehdizadeh, Mehdi Basic Clin Neurosci Research Papers INTRODUCTION: Exposure to 3-4, methylenedioxymethamphetamine (MDMA) leads to cell death. Herein, we studied the protective effects of ginger on MDMA- induced apoptosis. METHODS: 15 Sprague dawley male rats were administrated with 0, 10 mg/kg MDMA, or MDMA along with 100mg/kg ginger, IP for 7 days. Brains were removed to study the caspase 3, 8, and 9 expressions in the hippocampus by RT-PCR. Data was analyzed by SPSS 16 software using the one-way ANOVA test. RESULTS: MDMA treatment resulted in a significant increase in caspase 3, 8, and 9 as compared to the sham group (p < 0.001). Ginger administration however, appeared to significantly decrease the same (p < 0.001). DISCUSSION: Our findings suggest that ginger consumption may lead to the improvement of MDMA-induced neurotoxicity. Iranian Neuroscience Society 2013 /pmc/articles/PMC4202580/ /pubmed/25337365 Text en Copyright © 2013 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.
spellingShingle Research Papers
Asl, Sara Soleimani
Pourheydar, Bagher
Dabaghian, Fataneh
Nezhadi, Akram
Roointan, Amir
Mehdizadeh, Mehdi
Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title_full Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title_fullStr Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title_full_unstemmed Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title_short Ecstasy-Induced Caspase Expression Alters Following Ginger Treatment
title_sort ecstasy-induced caspase expression alters following ginger treatment
topic Research Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202580/
https://www.ncbi.nlm.nih.gov/pubmed/25337365
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