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Riluzole Ameliorates Harmaline-induced Tremor in Rat
INTRODUCTION: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Iranian Neuroscience Society
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202586/ https://www.ncbi.nlm.nih.gov/pubmed/25337372 |
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author | Shourmasti, Fatemeh Rahimi Goudarzi, Iran Abrari, Kataneh Salmani, Mahmoud Elahdadi Laskarbolouki, Taghi |
author_facet | Shourmasti, Fatemeh Rahimi Goudarzi, Iran Abrari, Kataneh Salmani, Mahmoud Elahdadi Laskarbolouki, Taghi |
author_sort | Shourmasti, Fatemeh Rahimi |
collection | PubMed |
description | INTRODUCTION: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat. METHODS: Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded. RESULTS: The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor. DISCUSSION: It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats. |
format | Online Article Text |
id | pubmed-4202586 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Iranian Neuroscience Society |
record_format | MEDLINE/PubMed |
spelling | pubmed-42025862014-10-21 Riluzole Ameliorates Harmaline-induced Tremor in Rat Shourmasti, Fatemeh Rahimi Goudarzi, Iran Abrari, Kataneh Salmani, Mahmoud Elahdadi Laskarbolouki, Taghi Basic Clin Neurosci Research Papers INTRODUCTION: Excessive olivo-cerebellar burst-firing occurs during harmaline-induced tremor. We hypothesized that antiglutamatergic agents would suppress harmaline tremor. From this point of view, the aim of the present study was to investigate the effects of riluzole on harmaline-induced tremor in rat. METHODS: Four groups of Wistar rats weighing 80–100 g were injected with harmaline (30 mg/ kg i.p.) for inducing experimental tremors. The rats in group 1 served as control, whereas the animals in groups 2, 3 and 4 were also given riluzole intraperitonealy at doses of 2, 4 and 8 mg/ kg 30 min before and 90 min after harmaline administration. The onset latency, intensity and duration of tremor were recorded. RESULTS: The results of this study demonstrated that riluzole could significantly increase latency period, and reduce duration and intensity of tremor. DISCUSSION: It is concluded that pretreatment of riluzole can ameliorate harmaline-induced tremor in rats. Iranian Neuroscience Society 2014 /pmc/articles/PMC4202586/ /pubmed/25337372 Text en Copyright © 2014 Iranian Neuroscience Society http://creativecommons.org/licenses/by-nc/3.0/ This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly. |
spellingShingle | Research Papers Shourmasti, Fatemeh Rahimi Goudarzi, Iran Abrari, Kataneh Salmani, Mahmoud Elahdadi Laskarbolouki, Taghi Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title | Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title_full | Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title_fullStr | Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title_full_unstemmed | Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title_short | Riluzole Ameliorates Harmaline-induced Tremor in Rat |
title_sort | riluzole ameliorates harmaline-induced tremor in rat |
topic | Research Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202586/ https://www.ncbi.nlm.nih.gov/pubmed/25337372 |
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