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Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae
Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersi...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2014
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202721/ https://www.ncbi.nlm.nih.gov/pubmed/25368845 http://dx.doi.org/10.3389/fcimb.2014.00146 |
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author | Heroven, Ann Kathrin Dersch, Petra |
author_facet | Heroven, Ann Kathrin Dersch, Petra |
author_sort | Heroven, Ann Kathrin |
collection | PubMed |
description | Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersinia pestis, are able to survive in a large variety of environmental reservoirs (e.g., soil, plants, insects) as well as warm-blooded animals (e.g., rodents, pigs, humans) with a particular preference for lymphatic tissues. In order to manage rapidly changing environmental conditions and interbacterial competition, Yersinia senses the nutritional composition during the course of an infection by special molecular devices, integrates this information and adapts its metabolism accordingly. In addition, nutrient availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Recent studies revealed that global regulatory factors such as the cAMP receptor protein (Crp) and the carbon storage regulator (Csr) system are part of a large network of transcriptional and posttranscriptional control strategies adjusting metabolic changes and virulence in response to temperature, ion and nutrient availability. Gained knowledge about the specific metabolic requirements and the correlation between metabolic and virulence gene expression that enable efficient host colonization led to the identification of new potential antimicrobial targets. |
format | Online Article Text |
id | pubmed-4202721 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-42027212014-11-03 Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae Heroven, Ann Kathrin Dersch, Petra Front Cell Infect Microbiol Microbiology Deciphering the principles how pathogenic bacteria adapt their metabolism to a specific host microenvironment is critical for understanding bacterial pathogenesis. The enteric pathogenic Yersinia species Yersinia pseudotuberculosis and Yersinia enterocolitica and the causative agent of plague, Yersinia pestis, are able to survive in a large variety of environmental reservoirs (e.g., soil, plants, insects) as well as warm-blooded animals (e.g., rodents, pigs, humans) with a particular preference for lymphatic tissues. In order to manage rapidly changing environmental conditions and interbacterial competition, Yersinia senses the nutritional composition during the course of an infection by special molecular devices, integrates this information and adapts its metabolism accordingly. In addition, nutrient availability has an impact on expression of virulence genes in response to C-sources, demonstrating a tight link between the pathogenicity of yersiniae and utilization of nutrients. Recent studies revealed that global regulatory factors such as the cAMP receptor protein (Crp) and the carbon storage regulator (Csr) system are part of a large network of transcriptional and posttranscriptional control strategies adjusting metabolic changes and virulence in response to temperature, ion and nutrient availability. Gained knowledge about the specific metabolic requirements and the correlation between metabolic and virulence gene expression that enable efficient host colonization led to the identification of new potential antimicrobial targets. Frontiers Media S.A. 2014-10-20 /pmc/articles/PMC4202721/ /pubmed/25368845 http://dx.doi.org/10.3389/fcimb.2014.00146 Text en Copyright © 2014 Heroven and Dersch. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Microbiology Heroven, Ann Kathrin Dersch, Petra Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title | Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title_full | Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title_fullStr | Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title_full_unstemmed | Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title_short | Coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
title_sort | coregulation of host-adapted metabolism and virulence by pathogenic yersiniae |
topic | Microbiology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202721/ https://www.ncbi.nlm.nih.gov/pubmed/25368845 http://dx.doi.org/10.3389/fcimb.2014.00146 |
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