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Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()

This study aimed to investigate the expression pattern and prognostic value of friend leukemia virus integration 1 (FLI-1) in nasopharyngeal carcinoma (NPC). Immunohistochemistry (IHC) staining of FLI-1 was performed in specimens from 198 untreated NPC patients. Ninety-nine patients were randomly as...

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Autores principales: Liang, Xuexia, Shi, Dingbo, Yun, Jingping, Mao, Yanping, Ouyang, Puyun, Su, Zhen, Fu, Jia, Hou, Jinghui, Deng, Wuguo, Xie, Fangyun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202802/
https://www.ncbi.nlm.nih.gov/pubmed/25171891
http://dx.doi.org/10.1016/j.tranon.2014.04.015
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author Liang, Xuexia
Shi, Dingbo
Yun, Jingping
Mao, Yanping
Ouyang, Puyun
Su, Zhen
Fu, Jia
Hou, Jinghui
Deng, Wuguo
Xie, Fangyun
author_facet Liang, Xuexia
Shi, Dingbo
Yun, Jingping
Mao, Yanping
Ouyang, Puyun
Su, Zhen
Fu, Jia
Hou, Jinghui
Deng, Wuguo
Xie, Fangyun
author_sort Liang, Xuexia
collection PubMed
description This study aimed to investigate the expression pattern and prognostic value of friend leukemia virus integration 1 (FLI-1) in nasopharyngeal carcinoma (NPC). Immunohistochemistry (IHC) staining of FLI-1 was performed in specimens from 198 untreated NPC patients. Ninety-nine patients were randomly assigned to the training set to analyze the prognostic value of FLI-1 and other clinicopathological characteristics, while the others were assigned to the testing set for validation. Clinicopathological data were compared using the Pearson chi-square test. Univariate and multivariate analyses were performed using the Cox proportional hazards model to test independent prognostic factors and calculate the hazard ratio (HR) and 95% confidence interval (CI). Cytoplasmic FLI-1 expression positively correlated with N stage, distant metastasis and death (P< 0.05) and also predicted poorer overall survival (OS) (P= 0.014), distant metastasis-free survival (DMFS) (P= 0.010), progression-free survival (PFS) (P= 0.031). In multivariate analysis, FLI-1 expression and clinical stage were both independent prognostic factors of poor OS and DMFS. Prognoses of patients in the training set, the testing set, and the entire set were clearly divided into four risk subgroups by supplementing FLI-1 with clinical stage. These results indicate that FLI-1 expression is an independent prognostic factor for NPC patients and suggest that supplementing FLI-1 with clinical stage could be helpful for more accurate risk definition.
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spelling pubmed-42028022014-10-27 Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma() Liang, Xuexia Shi, Dingbo Yun, Jingping Mao, Yanping Ouyang, Puyun Su, Zhen Fu, Jia Hou, Jinghui Deng, Wuguo Xie, Fangyun Transl Oncol Article This study aimed to investigate the expression pattern and prognostic value of friend leukemia virus integration 1 (FLI-1) in nasopharyngeal carcinoma (NPC). Immunohistochemistry (IHC) staining of FLI-1 was performed in specimens from 198 untreated NPC patients. Ninety-nine patients were randomly assigned to the training set to analyze the prognostic value of FLI-1 and other clinicopathological characteristics, while the others were assigned to the testing set for validation. Clinicopathological data were compared using the Pearson chi-square test. Univariate and multivariate analyses were performed using the Cox proportional hazards model to test independent prognostic factors and calculate the hazard ratio (HR) and 95% confidence interval (CI). Cytoplasmic FLI-1 expression positively correlated with N stage, distant metastasis and death (P< 0.05) and also predicted poorer overall survival (OS) (P= 0.014), distant metastasis-free survival (DMFS) (P= 0.010), progression-free survival (PFS) (P= 0.031). In multivariate analysis, FLI-1 expression and clinical stage were both independent prognostic factors of poor OS and DMFS. Prognoses of patients in the training set, the testing set, and the entire set were clearly divided into four risk subgroups by supplementing FLI-1 with clinical stage. These results indicate that FLI-1 expression is an independent prognostic factor for NPC patients and suggest that supplementing FLI-1 with clinical stage could be helpful for more accurate risk definition. Neoplasia Press 2014-08-27 /pmc/articles/PMC4202802/ /pubmed/25171891 http://dx.doi.org/10.1016/j.tranon.2014.04.015 Text en © 2014 The Authors. http://creativecommons.org/licenses/by-nc-nd/3.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/3.0/).
spellingShingle Article
Liang, Xuexia
Shi, Dingbo
Yun, Jingping
Mao, Yanping
Ouyang, Puyun
Su, Zhen
Fu, Jia
Hou, Jinghui
Deng, Wuguo
Xie, Fangyun
Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title_full Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title_fullStr Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title_full_unstemmed Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title_short Friend Leukemia Virus Integration 1 Expression Has Prognostic Significance in Nasopharyngeal Carcinoma()
title_sort friend leukemia virus integration 1 expression has prognostic significance in nasopharyngeal carcinoma()
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202802/
https://www.ncbi.nlm.nih.gov/pubmed/25171891
http://dx.doi.org/10.1016/j.tranon.2014.04.015
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