Cargando…

MOG transmembrane and cytoplasmic domains contain highly stimulatory T-cell epitopes in MS

OBJECTIVE: Recently, we reported that the 218 amino acid murine full-length myelin oligodendrocyte glycoprotein (MOG) contains novel T-cell epitopes p119-132, p181-195, and p186-200, located within its transmembrane and cytoplasmic domains, and that p119-132 is its immunodominant encephalitogenic T-...

Descripción completa

Detalles Bibliográficos
Autores principales:	Varrin-Doyer, Michel, Shetty, Aparna, Spencer, Collin M., Schulze-Topphoff, Ulf, Weber, Martin S., Bernard, Claude C.A., Forsthuber, Thomas, Cree, Bruce A.C., Slavin, Anthony J., Zamvil, Scott S.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Lippincott Williams & Wilkins 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4202926/ https://www.ncbi.nlm.nih.gov/pubmed/25340072 http://dx.doi.org/10.1212/NXI.0000000000000020

Ejemplares similares

Immunodominant T-cell epitopes of MOG reside in its transmembrane and cytoplasmic domains in EAE
por: Shetty, Aparna, et al.
Publicado: (2014)

Treatment of spontaneous EAE by laquinimod reduces Tfh, B cell aggregates, and disease progression
por: Varrin-Doyer, Michel, et al.
Publicado: (2016)

Aquaporin 4-Specific T Cells in Neuromyelitis Optica Exhibit a Th17 Bias and Recognize Clostridium ABC Transporter
por: Varrin-Doyer, Michel, et al.
Publicado: (2012)

Laquinimod, a Quinoline-3-Carboxamide, Induces Type II Myeloid Cells That Modulate Central Nervous System Autoimmunity
por: Schulze-Topphoff, Ulf, et al.
Publicado: (2012)

Gut microbiome analysis in neuromyelitis optica reveals overabundance of Clostridium perfringens
por: Cree, Bruce A. C., et al.
Publicado: (2016)

MHC class II–dependent B cell APC function is required for induction of CNS autoimmunity independent of myelin-specific antibodies
por: Molnarfi, Nicolas, et al.
Publicado: (2013)

Tob1 plays a critical role in the activation of encephalitogenic T cells in CNS autoimmunity
por: Schulze-Topphoff, Ulf, et al.
Publicado: (2013)

Immunodominant T Cell Determinants of Aquaporin-4, the Autoantigen Associated with Neuromyelitis Optica
por: Nelson, Patricia A., et al.
Publicado: (2010)

Does MOG Ig-positive AQP4-seronegative opticospinal inflammatory disease justify a diagnosis of NMO spectrum disorder?
por: Zamvil, Scott S., et al.
Publicado: (2015)

Glatiramer acetate treatment negatively regulates type I interferon signaling
por: Molnarfi, Nicolas, et al.
Publicado: (2015)

Epitope specificity of demyelinating MOG-specific autoantibody responses
por: Brehm, U., et al.
Publicado: (1998)

T cell deletional tolerance restricts AQP4 but not MOG CNS autoimmunity
por: Sagan, Sharon A., et al.
Publicado: (2023)

Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand
por: Howie, Duncan, et al.
Publicado: (2013)

Reduction of CD8(+) T lymphocytes in multiple sclerosis patients treated with dimethyl fumarate
por: Spencer, Collin M., et al.
Publicado: (2015)

Effect of the sphingosine-1-phosphate receptor modulator ozanimod on leukocyte subtypes in relapsing MS
por: Harris, Sarah, et al.
Publicado: (2020)

Correction: Secreted and Transmembrane 1A Is a Novel Co-Stimulatory Ligand
por: Howie, Duncan, et al.
Publicado: (2013)

The Change of Fingolimod Patient Profiles over Time: A Descriptive Analysis of Two Non-Interventional Studies PANGAEA and PANGAEA 2.0
por: Ziemssen, Tjalf, et al.
Publicado: (2021)

Targeting transmembrane-domain-less MOG expression to platelets prevents disease development in experimental autoimmune encephalomyelitis
por: Cai, Yuanhua, et al.
Publicado: (2022)

The Gut Microbiome in Neuromyelitis Optica
por: Zamvil, Scott S., et al.
Publicado: (2017)

Identification of circulating MOG-specific B cells in patients with MOG antibodies
por: Winklmeier, Stephan, et al.
Publicado: (2019)

The seven-transmembrane receptor, C5L2, is a stimulatory receptor on human mast cells
por: Pundir, Priyanka, et al.
Publicado: (2010)

Cytoplasmic Autoinhibition in HCN Channels is Regulated by the Transmembrane Region
por: Page, Dana A., et al.
Publicado: (2020)

MOG-expressing teratoma followed by MOG-IgG-positive optic neuritis
por: Wildemann, Brigitte, et al.
Publicado: (2020)

Syndecan Transmembrane Domain Specifically Regulates Downstream Signaling Events of the Transmembrane Receptor Cytoplasmic Domain
por: Hwang, Jisun, et al.
Publicado: (2021)

Engagement of distinct epitopes on CD43 induces different co‐stimulatory pathways in human T cells
por: Modak, Madhura, et al.
Publicado: (2016)

Analysis of progressive deletions of the transmembrane and cytoplasmic domains of influenza hemagglutinin
Publicado: (1986)

Protocol for visualizing conditional interaction between transmembrane and cytoplasmic proteins
por: Ooki, Takuya, et al.
Publicado: (2021)

The architecture of transmembrane and cytoplasmic juxtamembrane regions of Toll-like receptors
por: Kornilov, F. D., et al.
Publicado: (2023)

Cytoplasmic Citrate Flux Modulates the Immune Stimulatory NKG2D Ligand MICA in Cancer Cells
por: Møller, Sofie H., et al.
Publicado: (2020)

MOG antibody-associated diseases
por: Reindl, Markus, et al.
Publicado: (2015)

Uveitis, optic neuritis and MOG
por: Gupta, Pranjal, et al.
Publicado: (2020)

MOG Antibody–Associated Disease and Thymic Hyperplasia: From the National Multiple Sclerosis Society Case Conference Proceedings
por: Hurtubise, Brigitte, et al.
Publicado: (2022)

Conformational dynamics of the frameshift stimulatory structure in HIV-1
por: Ritchie, Dustin B., et al.
Publicado: (2017)

Transmembrane linkage between surface glycoproteins and components of the cytoplasm in neutrophil leukocytes
Publicado: (1981)

Transmembrane signaling and cytoplasmic signal conversion by dimeric transmembrane helix 2 and a linker domain of the DcuS sensor kinase
por: Stopp, Marius, et al.
Publicado: (2020)

Neurological update: MOG antibody disease
por: Wynford-Thomas, Ray, et al.
Publicado: (2018)

Coordinated Movement of Cytoplasmic and Transmembrane Domains of RyR1 upon Gating
por: Samsó, Montserrat, et al.
Publicado: (2009)

Allosteric Modulation of G Protein Coupled Receptors by Cytoplasmic, Transmembrane and Extracellular Ligands
por: Yanamala, Naveena, et al.
Publicado: (2010)

Positive Predictive Value of MOG-IgG for Clinically Defined MOG-AD Within a Real-World Cohort
por: Manzano, Giovanna S., et al.
Publicado: (2022)

Immunogenicity and Protective Efficacy of T-Cell Epitopes Derived From Potential Th1 Stimulatory Proteins of Leishmania (Leishmania) donovani
por: Joshi, Sumit, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_46mtlbkrcsekrlf5ujr5soj9e7