Interleukin-18 produced by bone marrow-derived stromal cells supports T-cell acute leukaemia progression

Development of novel therapies is critical for T-cell acute leukaemia (T-ALL). Here, we investigated the effect of inhibiting the MAPK/MEK/ERK pathway on T-ALL cell growth. Unexpectedly, MEK inhibitors (MEKi) enhanced growth of 70% of human T-ALL cell samples cultured on stromal cells independently...

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Detalles Bibliográficos
Autores principales: Uzan, Benjamin, Poglio, Sandrine, Gerby, Bastien, Wu, Ching-Lien, Gross, Julia, Armstrong, Florence, Calvo, Julien, Cahu, Xavier, Deswarte, Caroline, Dumont, Florent, Passaro, Diana, Besnard-Guérin, Corinne, Leblanc, Thierry, Baruchel, André, Landman-Parker, Judith, Ballerini, Paola, Baud, Véronique, Ghysdael, Jacques, Baleydier, Frédéric, Porteu, Francoise, Pflumio, Francoise
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Blackwell Publishing Ltd 2014
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203358/
https://www.ncbi.nlm.nih.gov/pubmed/24778454
http://dx.doi.org/10.1002/emmm.201303286

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