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Major Groove Orientation of the (2S)-N(6)-(2-Hydroxy-3-buten-1-yl)-2′-deoxyadenosine DNA Adduct Induced by 1,2-Epoxy-3-butene

[Image: see text] 1,3-Butadiene (BD) is an environmental and occupational toxicant classified as a human carcinogen. It is oxidized by cytochrome P450 monooxygenases to 1,2-epoxy-3-butene (EB), which alkylates DNA. BD exposures lead to large numbers of mutations at A:T base pairs even though alkylat...

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Detalles Bibliográficos
Autores principales:	Kowal, Ewa A., Wickramaratne, Susith, Kotapati, Srikanth, Turo, Michael, Tretyakova, Natalia, Stone, Michael P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Chemical Society 2014
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203389/ https://www.ncbi.nlm.nih.gov/pubmed/25238403 http://dx.doi.org/10.1021/tx500159w

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