Cargando…

Development of the preterm infant gut microbiome: a research priority

The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succe...

Descripción completa

Detalles Bibliográficos
Autores principales: Groer, Maureen W, Luciano, Angel A, Dishaw, Larry J, Ashmeade, Terri L, Miller, Elizabeth, Gilbert, Jack A
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203464/
https://www.ncbi.nlm.nih.gov/pubmed/25332768
http://dx.doi.org/10.1186/2049-2618-2-38
_version_ 1782340398892449792
author Groer, Maureen W
Luciano, Angel A
Dishaw, Larry J
Ashmeade, Terri L
Miller, Elizabeth
Gilbert, Jack A
author_facet Groer, Maureen W
Luciano, Angel A
Dishaw, Larry J
Ashmeade, Terri L
Miller, Elizabeth
Gilbert, Jack A
author_sort Groer, Maureen W
collection PubMed
description The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. The paper concludes with speculation about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host.
format Online
Article
Text
id pubmed-4203464
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-42034642014-10-21 Development of the preterm infant gut microbiome: a research priority Groer, Maureen W Luciano, Angel A Dishaw, Larry J Ashmeade, Terri L Miller, Elizabeth Gilbert, Jack A Microbiome Review The very low birth weight (VLBW) infant is at great risk for marked dysbiosis of the gut microbiome due to multiple factors, including physiological immaturity and prenatal/postnatal influences that disrupt the development of a normal gut flora. However, little is known about the developmental succession of the microbiota in preterm infants as they grow and mature. This review provides a synthesis of our understanding of the normal development of the infant gut microbiome and contrasts this with dysbiotic development in the VLBW infant. The role of human milk in normal gut microbial development is emphasized, along with the role of the gut microbiome in immune development and gastroenteric health. Current research provides evidence that the gut microbiome interacts extensively with many physiological systems and metabolic processes in the developing infant. However, to the best of our knowledge, there are currently no studies prospectively mapping the gut microbiome of VLBW infants through early childhood. This knowledge gap must be filled to inform a healthcare system that can provide for the growth, health, and development of VLBW infants. The paper concludes with speculation about how the VLBW infants’ gut microbiome might function through host-microbe interactions to contribute to the sequelae of preterm birth, including its influence on growth, development, and general health of the infant host. BioMed Central 2014-10-13 /pmc/articles/PMC4203464/ /pubmed/25332768 http://dx.doi.org/10.1186/2049-2618-2-38 Text en Copyright © 2014 Groer et al.; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/4.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
spellingShingle Review
Groer, Maureen W
Luciano, Angel A
Dishaw, Larry J
Ashmeade, Terri L
Miller, Elizabeth
Gilbert, Jack A
Development of the preterm infant gut microbiome: a research priority
title Development of the preterm infant gut microbiome: a research priority
title_full Development of the preterm infant gut microbiome: a research priority
title_fullStr Development of the preterm infant gut microbiome: a research priority
title_full_unstemmed Development of the preterm infant gut microbiome: a research priority
title_short Development of the preterm infant gut microbiome: a research priority
title_sort development of the preterm infant gut microbiome: a research priority
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203464/
https://www.ncbi.nlm.nih.gov/pubmed/25332768
http://dx.doi.org/10.1186/2049-2618-2-38
work_keys_str_mv AT groermaureenw developmentofthepreterminfantgutmicrobiomearesearchpriority
AT lucianoangela developmentofthepreterminfantgutmicrobiomearesearchpriority
AT dishawlarryj developmentofthepreterminfantgutmicrobiomearesearchpriority
AT ashmeadeterril developmentofthepreterminfantgutmicrobiomearesearchpriority
AT millerelizabeth developmentofthepreterminfantgutmicrobiomearesearchpriority
AT gilbertjacka developmentofthepreterminfantgutmicrobiomearesearchpriority