When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma

In metastatic melanoma patients, circulating natural killer (NK) cells display phenotypic and functional alterations that appear to correlate with the duration of stage IV disease. Moreover, specific NK cell subsets that exhibit robust tumoricidal functions upon activation by cytokines infiltrate th...

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Autores principales: Messaoudene, Meriem, Avril, Marie-Françoise, Caignard, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203499/
https://www.ncbi.nlm.nih.gov/pubmed/25340005
http://dx.doi.org/10.4161/onci.28048
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author Messaoudene, Meriem
Avril, Marie-Françoise
Caignard, Anne
author_facet Messaoudene, Meriem
Avril, Marie-Françoise
Caignard, Anne
author_sort Messaoudene, Meriem
collection PubMed
description In metastatic melanoma patients, circulating natural killer (NK) cells display phenotypic and functional alterations that appear to correlate with the duration of stage IV disease. Moreover, specific NK cell subsets that exhibit robust tumoricidal functions upon activation by cytokines infiltrate the diseased lymph nodes of these patients. These data suggest that NK cells may be harnessed for the development of novel combinatorial immunotherapies against melanoma.
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spelling pubmed-42034992015-02-14 When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma Messaoudene, Meriem Avril, Marie-Françoise Caignard, Anne Oncoimmunology Author's View In metastatic melanoma patients, circulating natural killer (NK) cells display phenotypic and functional alterations that appear to correlate with the duration of stage IV disease. Moreover, specific NK cell subsets that exhibit robust tumoricidal functions upon activation by cytokines infiltrate the diseased lymph nodes of these patients. These data suggest that NK cells may be harnessed for the development of novel combinatorial immunotherapies against melanoma. Landes Bioscience 2014-02-14 /pmc/articles/PMC4203499/ /pubmed/25340005 http://dx.doi.org/10.4161/onci.28048 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Messaoudene, Meriem
Avril, Marie-Françoise
Caignard, Anne
When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title_full When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title_fullStr When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title_full_unstemmed When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title_short When unity makes strength: Combinatorial NK cell-based immunotherapies against melanoma
title_sort when unity makes strength: combinatorial nk cell-based immunotherapies against melanoma
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203499/
https://www.ncbi.nlm.nih.gov/pubmed/25340005
http://dx.doi.org/10.4161/onci.28048
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