The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages

Brain tumor-initiating cells (BTICs) become less tumorigenic when co-cultured with microglia/macrophages (M/Ms) isolated from subjects not affected by glioma, but not when exposed to the M/Ms of glioma patients. Microglial cells and macrophages from glioma patients, however, can be reactivated by no...

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Detalles Bibliográficos
Autores principales: Sarkar, Susobhan, Yong, V Wee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203533/
https://www.ncbi.nlm.nih.gov/pubmed/25340004
http://dx.doi.org/10.4161/onci.28047
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author Sarkar, Susobhan
Yong, V Wee
author_facet Sarkar, Susobhan
Yong, V Wee
author_sort Sarkar, Susobhan
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description Brain tumor-initiating cells (BTICs) become less tumorigenic when co-cultured with microglia/macrophages (M/Ms) isolated from subjects not affected by glioma, but not when exposed to the M/Ms of glioma patients. Microglial cells and macrophages from glioma patients, however, can be reactivated by non-toxic doses of amphotericin B to curb the growth of BTICs in vitro and in vivo.
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spelling pubmed-42035332015-02-14 The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages Sarkar, Susobhan Yong, V Wee Oncoimmunology Author's View Brain tumor-initiating cells (BTICs) become less tumorigenic when co-cultured with microglia/macrophages (M/Ms) isolated from subjects not affected by glioma, but not when exposed to the M/Ms of glioma patients. Microglial cells and macrophages from glioma patients, however, can be reactivated by non-toxic doses of amphotericin B to curb the growth of BTICs in vitro and in vivo. Landes Bioscience 2014-02-14 /pmc/articles/PMC4203533/ /pubmed/25340004 http://dx.doi.org/10.4161/onci.28047 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Sarkar, Susobhan
Yong, V Wee
The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title_full The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title_fullStr The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title_full_unstemmed The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title_short The battle for the brain: Brain tumor-initiating cells vs. microglia/macrophages
title_sort battle for the brain: brain tumor-initiating cells vs. microglia/macrophages
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203533/
https://www.ncbi.nlm.nih.gov/pubmed/25340004
http://dx.doi.org/10.4161/onci.28047
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