Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites

Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic cells as a critical mediator of mucosal anti-cancer immunosurveillance. This dis...

Descripción completa

Detalles Bibliográficos
Autores principales: Baker, Kristi, Rath, Timo, Pyzik, Michal, Blumberg, Richard S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Author's View
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203632/
https://www.ncbi.nlm.nih.gov/pubmed/25339998
http://dx.doi.org/10.4161/onci.27844
_version_ 1782340413950001152
author Baker, Kristi
Rath, Timo
Pyzik, Michal
Blumberg, Richard S
author_facet Baker, Kristi
Rath, Timo
Pyzik, Michal
Blumberg, Richard S
author_sort Baker, Kristi
collection PubMed
description Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic cells as a critical mediator of mucosal anti-cancer immunosurveillance. This discovery extends our understanding of neonatal Fc receptors, defines a role for tumor-reactive IgGs, and identifies an avenue for the development of novel anti-cancer therapeutics.
format Online
Article
Text
id pubmed-4203632
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-42036322015-02-14 Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites Baker, Kristi Rath, Timo Pyzik, Michal Blumberg, Richard S Oncoimmunology Author's View Mucosal boundaries, which are immunologically tolerogenic, and is further enhanced by undergo malignant transformation at high rates. We have identified the expression of neonatal Fc receptor for IgG (FcRn) by dendritic cells as a critical mediator of mucosal anti-cancer immunosurveillance. This discovery extends our understanding of neonatal Fc receptors, defines a role for tumor-reactive IgGs, and identifies an avenue for the development of novel anti-cancer therapeutics. Landes Bioscience 2014-02-14 /pmc/articles/PMC4203632/ /pubmed/25339998 http://dx.doi.org/10.4161/onci.27844 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Author's View
Baker, Kristi
Rath, Timo
Pyzik, Michal
Blumberg, Richard S
Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title_full Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title_fullStr Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title_full_unstemmed Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title_short Neonatal Fc receptors for IgG drive CD8(+) T cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
title_sort neonatal fc receptors for igg drive cd8(+) t cell-mediated anti-cancer immunosurveillance at tolerogenic mucosal sites
topic Author's View
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203632/
https://www.ncbi.nlm.nih.gov/pubmed/25339998
http://dx.doi.org/10.4161/onci.27844
work_keys_str_mv AT bakerkristi neonatalfcreceptorsforiggdrivecd8tcellmediatedanticancerimmunosurveillanceattolerogenicmucosalsites
AT rathtimo neonatalfcreceptorsforiggdrivecd8tcellmediatedanticancerimmunosurveillanceattolerogenicmucosalsites
AT pyzikmichal neonatalfcreceptorsforiggdrivecd8tcellmediatedanticancerimmunosurveillanceattolerogenicmucosalsites
AT blumbergrichards neonatalfcreceptorsforiggdrivecd8tcellmediatedanticancerimmunosurveillanceattolerogenicmucosalsites

Ejemplares similares