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Evaluation of the Highly Variable Agomelatine Pharmacokinetics in Chinese Healthy Subjects to Support Bioequivalence Study

OBJECTIVES: We aim to obtain the intra-subject coefficient of variability of a highly variable antidepressant agomelatine in humans, and propose an adjusted bioequivalence assessment strategy. METHODS: A single-dose, randomized crossover design was conducted in four periods (reference administered t...

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Detalles Bibliográficos
Autores principales:	Pei, Qi, Wang, Yan, Hu, Zhe-Yi, Liu, Shi-Kun, Tan, Hong-Yi, Guo, Cheng-Xian, Zhang, Ran-Ran, Xiang, Yu-Xia, Huang, Jie, Huang, Lu, Yuan, Hong, Yang, Guo-Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2014
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203722/ https://www.ncbi.nlm.nih.gov/pubmed/25330096 http://dx.doi.org/10.1371/journal.pone.0109300

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