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The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles
The presence of Ca(2+)-activated Cl(–) currents (I(Cl(Ca))) in vascular smooth muscle cells (VSMCs) is well established. I(Cl(Ca)) are supposedly important for arterial contraction by linking changes in [Ca(2+)](i) and membrane depolarization. Bestrophins and some members of the TMEM16 protein famil...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Landes Bioscience
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203738/ https://www.ncbi.nlm.nih.gov/pubmed/25478625 http://dx.doi.org/10.4161/chan.29531 |
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author | Dam, Vibeke Secher Boedtkjer, Donna MB Aalkjaer, Christian Matchkov, Vladimir |
author_facet | Dam, Vibeke Secher Boedtkjer, Donna MB Aalkjaer, Christian Matchkov, Vladimir |
author_sort | Dam, Vibeke Secher |
collection | PubMed |
description | The presence of Ca(2+)-activated Cl(–) currents (I(Cl(Ca))) in vascular smooth muscle cells (VSMCs) is well established. I(Cl(Ca)) are supposedly important for arterial contraction by linking changes in [Ca(2+)](i) and membrane depolarization. Bestrophins and some members of the TMEM16 protein family were recently associated with I(Cl(Ca)). Two distinct I(Cl(Ca)) are characterized in VSMCs; the cGMP-dependent I(Cl(Ca)) dependent upon bestrophin expression and the ‘classical’ Ca(2+)-activated Cl(–) current, which is bestrophin-independent. Interestingly, TMEM16A is essential for both the cGMP-dependent and the classical I(Cl(Ca)). Furthermore, TMEM16A has a role in arterial contraction while bestrophins do not. TMEM16A’s role in the contractile response cannot be explained however only by a simple suppression of the depolarization by Cl(–) channels. It is suggested that TMEM16A expression modulates voltage-gated Ca(2+) influx in a voltage-independent manner and recent studies also demonstrate a complex role of TMEM16A in modulating other membrane proteins. |
format | Online Article Text |
id | pubmed-4203738 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Landes Bioscience |
record_format | MEDLINE/PubMed |
spelling | pubmed-42037382015-07-01 The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles Dam, Vibeke Secher Boedtkjer, Donna MB Aalkjaer, Christian Matchkov, Vladimir Channels (Austin) Review The presence of Ca(2+)-activated Cl(–) currents (I(Cl(Ca))) in vascular smooth muscle cells (VSMCs) is well established. I(Cl(Ca)) are supposedly important for arterial contraction by linking changes in [Ca(2+)](i) and membrane depolarization. Bestrophins and some members of the TMEM16 protein family were recently associated with I(Cl(Ca)). Two distinct I(Cl(Ca)) are characterized in VSMCs; the cGMP-dependent I(Cl(Ca)) dependent upon bestrophin expression and the ‘classical’ Ca(2+)-activated Cl(–) current, which is bestrophin-independent. Interestingly, TMEM16A is essential for both the cGMP-dependent and the classical I(Cl(Ca)). Furthermore, TMEM16A has a role in arterial contraction while bestrophins do not. TMEM16A’s role in the contractile response cannot be explained however only by a simple suppression of the depolarization by Cl(–) channels. It is suggested that TMEM16A expression modulates voltage-gated Ca(2+) influx in a voltage-independent manner and recent studies also demonstrate a complex role of TMEM16A in modulating other membrane proteins. Landes Bioscience 2014-07-01 2014-06-25 /pmc/articles/PMC4203738/ /pubmed/25478625 http://dx.doi.org/10.4161/chan.29531 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited. |
spellingShingle | Review Dam, Vibeke Secher Boedtkjer, Donna MB Aalkjaer, Christian Matchkov, Vladimir The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title | The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title_full | The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title_fullStr | The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title_full_unstemmed | The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title_short | The bestrophin- and TMEM16A-associated Ca(2+)-activated Cl(–) channels in vascular smooth muscles |
title_sort | bestrophin- and tmem16a-associated ca(2+)-activated cl(–) channels in vascular smooth muscles |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203738/ https://www.ncbi.nlm.nih.gov/pubmed/25478625 http://dx.doi.org/10.4161/chan.29531 |
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