Cargando…

Organelle biogenesis and interorganellar connections: Better in contact than in isolation

Membrane contact sites (MCSs) allow the exchange of molecules and information between organelles, even when their membranes cannot fuse directly. In recent years, a number of functions have been attributed to these contacts, highlighting their critical role in cell homeostasis. Although inter-organe...

Descripción completa

Detalles Bibliográficos
Autores principales: Daniele, Tiziana, Schiaffino, Maria Vittoria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Landes Bioscience 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203768/
https://www.ncbi.nlm.nih.gov/pubmed/25346798
http://dx.doi.org/10.4161/cib.29587
_version_ 1782340428284035072
author Daniele, Tiziana
Schiaffino, Maria Vittoria
author_facet Daniele, Tiziana
Schiaffino, Maria Vittoria
author_sort Daniele, Tiziana
collection PubMed
description Membrane contact sites (MCSs) allow the exchange of molecules and information between organelles, even when their membranes cannot fuse directly. In recent years, a number of functions have been attributed to these contacts, highlighting their critical role in cell homeostasis. Although inter-organellar connections typically involve the endoplasmic reticulum (ER), we recently reported the presence of a novel MCSs between melanosomes and mitochondria. Melanosome-mitochondrion contacts appear mediated by fibrillar bridges resembling the protein tethers linking mitochondria and the ER, both for their ultrastructural features and the involvement of Mitofusin 2. The frequency of these connections correlates spatially and timely with melanosome biogenesis, suggesting a functional link between the 2 processes and in general that organelle biogenesis in the secretory pathway requires interorganellar crosstalks at multiple steps. Here, we summarize the different functions attributed to MCSs, and discuss their possible relevance for the newly identified melanosome-mitochondrion liaison.
format Online
Article
Text
id pubmed-4203768
institution National Center for Biotechnology Information
language English
publishDate 2014
publisher Landes Bioscience
record_format MEDLINE/PubMed
spelling pubmed-42037682014-10-24 Organelle biogenesis and interorganellar connections: Better in contact than in isolation Daniele, Tiziana Schiaffino, Maria Vittoria Commun Integr Biol Review Membrane contact sites (MCSs) allow the exchange of molecules and information between organelles, even when their membranes cannot fuse directly. In recent years, a number of functions have been attributed to these contacts, highlighting their critical role in cell homeostasis. Although inter-organellar connections typically involve the endoplasmic reticulum (ER), we recently reported the presence of a novel MCSs between melanosomes and mitochondria. Melanosome-mitochondrion contacts appear mediated by fibrillar bridges resembling the protein tethers linking mitochondria and the ER, both for their ultrastructural features and the involvement of Mitofusin 2. The frequency of these connections correlates spatially and timely with melanosome biogenesis, suggesting a functional link between the 2 processes and in general that organelle biogenesis in the secretory pathway requires interorganellar crosstalks at multiple steps. Here, we summarize the different functions attributed to MCSs, and discuss their possible relevance for the newly identified melanosome-mitochondrion liaison. Landes Bioscience 2014-06-23 /pmc/articles/PMC4203768/ /pubmed/25346798 http://dx.doi.org/10.4161/cib.29587 Text en Copyright © 2014 Landes Bioscience http://creativecommons.org/licenses/by-nc/3.0/ This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.
spellingShingle Review
Daniele, Tiziana
Schiaffino, Maria Vittoria
Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title_full Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title_fullStr Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title_full_unstemmed Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title_short Organelle biogenesis and interorganellar connections: Better in contact than in isolation
title_sort organelle biogenesis and interorganellar connections: better in contact than in isolation
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203768/
https://www.ncbi.nlm.nih.gov/pubmed/25346798
http://dx.doi.org/10.4161/cib.29587
work_keys_str_mv AT danieletiziana organellebiogenesisandinterorganellarconnectionsbetterincontactthaninisolation
AT schiaffinomariavittoria organellebiogenesisandinterorganellarconnectionsbetterincontactthaninisolation