Apaf-1 Inhibitors Protect from Unwanted Cell Death in In Vivo Models of Kidney Ischemia and Chemotherapy Induced Ototoxicity

BACKGROUND: Excessive apoptosis induces unwanted cell death and promotes pathological conditions. Drug discovery efforts aimed at decreasing apoptotic damage initially targeted the inhibition of effector caspases. Although such inhibitors were effective, safety problems led to slow pharmacological d...

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Detalles Bibliográficos
Autores principales: Orzáez, Mar, Sancho, Mónica, Marchán, Sandra, Mondragón, Laura, Montava, Rebeca, Valero, Juan García, Landeta, Olatz, Basañez, Gorka, Carbajo, Rodrigo J., Pineda-Lucena, Antonio, Bujons, Jordi, Moure, Alejandra, Messeguer, Angel, Lagunas, Carmen, Herrero, Carmen, Pérez-Payá, Enrique
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2014
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203855/
https://www.ncbi.nlm.nih.gov/pubmed/25330150
http://dx.doi.org/10.1371/journal.pone.0110979

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