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Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes
BACKGROUND: Gene expression is epigenetically regulated by a combination of histone modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich promoters are typically unmethylated, marked with histone modifications such as H3K4me3, and are highly active. During neopla...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203885/ https://www.ncbi.nlm.nih.gov/pubmed/25239471 http://dx.doi.org/10.1186/s13059-014-0469-0 |