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Global loss of DNA methylation uncovers intronic enhancers in genes showing expression changes

BACKGROUND: Gene expression is epigenetically regulated by a combination of histone modifications and methylation of CpG dinucleotides in promoters. In normal cells, CpG-rich promoters are typically unmethylated, marked with histone modifications such as H3K4me3, and are highly active. During neopla...

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Detalles Bibliográficos
Autores principales:	Blattler, Adam, Yao, Lijing, Witt, Heather, Guo, Yu, Nicolet, Charles M, Berman, Benjamin P, Farnham, Peggy J
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2014
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203885/ https://www.ncbi.nlm.nih.gov/pubmed/25239471 http://dx.doi.org/10.1186/s13059-014-0469-0

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