Cargando…
Regulation of YAP by mTOR and autophagy reveals a therapeutic target of tuberous sclerosis complex
Genetic studies have shown that the tuberous sclerosis complex (TSC) 1–TSC2–mammalian target of Rapamycin (mTOR) and the Hippo–Yes-associated protein 1 (YAP) pathways are master regulators of organ size, which are often involved in tumorigenesis. The crosstalk between these signal transduction pathw...
Autores principales: | Liang, Ning, Zhang, Chi, Dill, Patricia, Panasyuk, Ganna, Pion, Delphine, Koka, Vonda, Gallazzini, Morgan, Olson, Eric N., Lam, Hilaire, Henske, Elizabeth P., Dong, Zheng, Apte, Udayan, Pallet, Nicolas, Johnson, Randy L., Terzi, Fabiola, Kwiatkowski, David J., Scoazec, Jean-Yves, Martignoni, Guido, Pende, Mario |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Rockefeller University Press
2014
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203941/ https://www.ncbi.nlm.nih.gov/pubmed/25288394 http://dx.doi.org/10.1084/jem.20140341 |
Ejemplares similares
-
New insights into the pathophysiology of the tuberous sclerosis complex: Crosstalk of mTOR- and hippo-YAP pathways in cell growth
por: Dill, Patricia E, et al.
Publicado: (2015) -
YAP enters the mTOR pathway to promote tuberous sclerosis complex
por: Liang, Ning, et al.
Publicado: (2015) -
ZRF1 is a novel S6 kinase substrate that drives the senescence programme
por: Barilari, Manuela, et al.
Publicado: (2017) -
Spectrum of germline and somatic mitochondrial DNA variants in Tuberous Sclerosis Complex
por: Giannikou, Krinio, et al.
Publicado: (2023) -
mTOR and S6K1 drive polycystic kidney by the control of Afadin-dependent oriented cell division
por: Bonucci, Martina, et al.
Publicado: (2020)