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Myeloproliferative neoplasms can be initiated from a single hematopoietic stem cell expressing JAK2-V617F

The majority of patients with myeloproliferative neoplasms (MPNs) carry a somatic JAK2-V617F mutation. Because additional mutations can precede JAK2-V617F, it is questioned whether JAK2-V617F alone can initiate MPN. Several mouse models have demonstrated that JAK2-V617F can cause MPN; however, in al...

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Detalles Bibliográficos
Autores principales:	Lundberg, Pontus, Takizawa, Hitoshi, Kubovcakova, Lucia, Guo, Guoji, Hao-Shen, Hui, Dirnhofer, Stephan, Orkin, Stuart H., Manz, Markus G., Skoda, Radek C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Rockefeller University Press 2014
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203945/ https://www.ncbi.nlm.nih.gov/pubmed/25288396 http://dx.doi.org/10.1084/jem.20131371

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