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Immunoglobulin E plays an immunoregulatory role in lupus

The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well as in mice carrying both a deletion of FcγRIIB and the chromosomal translocation of Y-linked...

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Autores principales: Dema, Barbara, Charles, Nicolas, Pellefigues, Christophe, Ricks, Tiffany K., Suzuki, Ryo, Jiang, Chao, Scheffel, Jorg, Hasni, Sarfaraz, Hoffman, Victoria, Jablonski, Mathieu, Sacré, Karim, Gobert, Delphine, Papo, Thomas, Daugas, Eric, Crampton, Steve, Bolland, Silvia, Rivera, Juan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Rockefeller University Press 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203948/
https://www.ncbi.nlm.nih.gov/pubmed/25267791
http://dx.doi.org/10.1084/jem.20140066
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author Dema, Barbara
Charles, Nicolas
Pellefigues, Christophe
Ricks, Tiffany K.
Suzuki, Ryo
Jiang, Chao
Scheffel, Jorg
Hasni, Sarfaraz
Hoffman, Victoria
Jablonski, Mathieu
Sacré, Karim
Gobert, Delphine
Papo, Thomas
Daugas, Eric
Crampton, Steve
Bolland, Silvia
Rivera, Juan
author_facet Dema, Barbara
Charles, Nicolas
Pellefigues, Christophe
Ricks, Tiffany K.
Suzuki, Ryo
Jiang, Chao
Scheffel, Jorg
Hasni, Sarfaraz
Hoffman, Victoria
Jablonski, Mathieu
Sacré, Karim
Gobert, Delphine
Papo, Thomas
Daugas, Eric
Crampton, Steve
Bolland, Silvia
Rivera, Juan
author_sort Dema, Barbara
collection PubMed
description The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well as in mice carrying both a deletion of FcγRIIB and the chromosomal translocation of Y-linked autoimmune acceleration (Yaa) that hastens and results in a more aggressive lupuslike disease in these mice. The findings show that deficiency of IgE delays disease development and severity as demonstrated by reduced autoantibody production and amelioration of organ pathologies. This was associated with decreased numbers of plasma cells and reduced levels of IgG2b and IgG3. Unexpectedly, the loss of IgE also caused a striking decrease of immune cell infiltration in secondary lymphoid organs with a marked effect on the presence of dendritic cells, monocytes, neutrophils, and eosinophils in these organs and decreased activation of basophils. The presence of autoreactive IgE in human systemic lupus erythematosus subjects was also associated with increased basophil activation and enhanced disease activity. These findings argue that IgE facilitates the amplification of autoimmune inflammation.
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spelling pubmed-42039482015-04-20 Immunoglobulin E plays an immunoregulatory role in lupus Dema, Barbara Charles, Nicolas Pellefigues, Christophe Ricks, Tiffany K. Suzuki, Ryo Jiang, Chao Scheffel, Jorg Hasni, Sarfaraz Hoffman, Victoria Jablonski, Mathieu Sacré, Karim Gobert, Delphine Papo, Thomas Daugas, Eric Crampton, Steve Bolland, Silvia Rivera, Juan J Exp Med Brief Definitive Report The (patho)physiological role of IgE in nonallergic inflammatory diseases is not well understood. Here, we explored the effect of IgE deficiency on the inflammatory response in FcγRIIB-deficient mice as well as in mice carrying both a deletion of FcγRIIB and the chromosomal translocation of Y-linked autoimmune acceleration (Yaa) that hastens and results in a more aggressive lupuslike disease in these mice. The findings show that deficiency of IgE delays disease development and severity as demonstrated by reduced autoantibody production and amelioration of organ pathologies. This was associated with decreased numbers of plasma cells and reduced levels of IgG2b and IgG3. Unexpectedly, the loss of IgE also caused a striking decrease of immune cell infiltration in secondary lymphoid organs with a marked effect on the presence of dendritic cells, monocytes, neutrophils, and eosinophils in these organs and decreased activation of basophils. The presence of autoreactive IgE in human systemic lupus erythematosus subjects was also associated with increased basophil activation and enhanced disease activity. These findings argue that IgE facilitates the amplification of autoimmune inflammation. The Rockefeller University Press 2014-10-20 /pmc/articles/PMC4203948/ /pubmed/25267791 http://dx.doi.org/10.1084/jem.20140066 Text en This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).
spellingShingle Brief Definitive Report
Dema, Barbara
Charles, Nicolas
Pellefigues, Christophe
Ricks, Tiffany K.
Suzuki, Ryo
Jiang, Chao
Scheffel, Jorg
Hasni, Sarfaraz
Hoffman, Victoria
Jablonski, Mathieu
Sacré, Karim
Gobert, Delphine
Papo, Thomas
Daugas, Eric
Crampton, Steve
Bolland, Silvia
Rivera, Juan
Immunoglobulin E plays an immunoregulatory role in lupus
title Immunoglobulin E plays an immunoregulatory role in lupus
title_full Immunoglobulin E plays an immunoregulatory role in lupus
title_fullStr Immunoglobulin E plays an immunoregulatory role in lupus
title_full_unstemmed Immunoglobulin E plays an immunoregulatory role in lupus
title_short Immunoglobulin E plays an immunoregulatory role in lupus
title_sort immunoglobulin e plays an immunoregulatory role in lupus
topic Brief Definitive Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203948/
https://www.ncbi.nlm.nih.gov/pubmed/25267791
http://dx.doi.org/10.1084/jem.20140066
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