The Brucella TIR domain containing proteins BtpA and BtpB have a structural WxxxE motif important for protection against microtubule depolymerisation

BACKGROUND: The TIR domain-containing proteins BtpA/Btp1/TcpB and BtpB are translocated into host cells by the facultative intracellular bacterial pathogen Brucella. Here, they interfere with Toll like receptor signalling to temper the host inflammatory response. BtpA has also been found to modulate...

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Detalles Bibliográficos
Autores principales: Felix, Christine, Kaplan Türköz, Burcu, Ranaldi, Sebastien, Koelblen, Thomas, Terradot, Laurent, O’Callaghan, David, Vergunst, Annette Caroline
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2014
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4203976/
https://www.ncbi.nlm.nih.gov/pubmed/25304327
http://dx.doi.org/10.1186/s12964-014-0053-y

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