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Systemic exosomal siRNA delivery reduced alpha-synuclein aggregates in brains of transgenic mice

Alpha-synuclein (α-Syn) aggregates are the main component of Lewy bodies, which are the characteristic pathological feature in Parkinson's disease (PD) brain. Evidence that α-Syn aggregation can be propagated between neurones has led to the suggestion that this mechanism is responsible for the...

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Detalles Bibliográficos
Autores principales:	Cooper, J Mark, Wiklander, PB Oscar, Nordin, Joel Z, Al-Shawi, Raya, Wood, Matthew J, Vithlani, Mansi, Schapira, Anthony H V, Simons, J Paul, El-Andaloussi, Samir, Alvarez-Erviti, Lydia
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BlackWell Publishing Ltd 2014
Materias:	Featured Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4204174/ https://www.ncbi.nlm.nih.gov/pubmed/25112864 http://dx.doi.org/10.1002/mds.25978

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